1
Charles Allerson, Balkrishen Bhat, Eric E Swayze, Thazha P Prakash: Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation. Isis Pharmaceuticals, Jones Day, April 13, 2010: US07696345 (108 worldwide citation)

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucl ...


2
Balkrishen Bhat, Jie Xia, Punit P Seth, Guillermo Vasquez, Michael T Migawa, Charles Allerson, Thazha P Prakash, Eric E Swayze: Compounds and methods for synthesis of bicyclic nucleic acid analogs. Isis Pharmaceuticals, Jones Day, August 4, 2009: US07569686 (91 worldwide citation)

The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds. Oligomeric compounds comprising these bicyclic nucleosides have enhanced properties such as increased nuc ...


3
Vincent P Stanton Jr, Jia Liu Wolfe, Tomohiko Kawate, Charles Allerson, Gregory L Verdine: Base-modified nucleotides and cleavage of polynucleotides incorporating them. Variagenics, Bernard F Rose Esq, Bingham McCutchen, August 26, 2003: US06610492 (71 worldwide citation)

The present invention is directed to novel base-modified nucleotides and methods for their use in the preparation and cleavage of modified polynucleotides.


4
Charles Allerson, Balkrishen Bhat, Eric E Swayze, Thazha P Prakash: Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation. Isis Pharmaceuticals, Isis Patent Dept Jones Day, February 28, 2012: US08124745 (15 worldwide citation)

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucl ...


5
Charles Allerson, Balkrishen Bhat, Anne B Eldrup, Muthiah Manoharan, Richard H Griffey, Brenda F Baker, Eric E Swayze: Compositions comprising alternating 2′-modified nucleosides for use in gene modulation. Isis Pharmaceuticals, Isis Pharmaceuticals Patent Dept, December 10, 2013: US08604183 (5 worldwide citation)

The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression ...


6
Eric E Swayze, Andrew M Siwkowski, Balkrishen Bhat, Thazha P Prakash, Charles Allerson, Punit P Seth: Tetrahydropyran nucleic acid analogs. Isis Pharmaceuticals, Isis Pharmaceuticals Patent Dept Jones Day, January 3, 2012: US08088904 (5 worldwide citation)

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing proper ...


7
Balkrishen Bhat, Prasad Dande, Thazha P Prakash, Charles Allerson, Eric E Swayze, Richard H Griffey: Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation. Isis Pharmaceuticals, January 25, 2011: US07875733 (4 worldwide citation)

The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.


8
Balkrishen Bhat, Prasad Dande, Thazha P Prakash, Charles Allerson, Eric E Swayze, Richard H Griffey: Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation. Isis Pharmaceuticals, Jones Day, May 10, 2011: US07939677 (4 worldwide citation)

The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.


9
Eric E Swayze, Andrew M Siwkowski, Balkrishen Bhat, Thazha P Prakash, Charles Allerson, Punit P Seth: Tetrahydropyran nucleic acid analogs. Isis Pharmaceuticals, Isis Pharmaceuticals, Casimir Jones, April 14, 2015: US09005906 (2 worldwide citation)

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing proper ...


10
Eric E Swayze, Andrew M Siwkowski, Balkrishen Bhat, Thazha P Prakash, Charles Allerson, Punit P Seth: Tetrahydropyran nucleic acid analogs. Isis Pharmaceuticals, Isis Pharmaceuticals, May 14, 2013: US08440803 (2 worldwide citation)

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing proper ...