1
Joseph P Vacanti, Charles A Vacanti, Robert S Langer: Neomorphogenesis of cartilage in vivo from cell culture. Massachusetts Institute of Technology, Children s Hospital, Kilpatrick & Cody, August 20, 1991: US05041138 (401 worldwide citation)

Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate c ...


2
Linda Griffith Cima, Anthony Atala, Charles A Vacanti, Keith T Paige: Tissue formation by injecting a cell-polymeric solution that gels in vivo. Massachusetts Institute of Technology, Arnall Golden & Gregory, January 20, 1998: US05709854 (221 worldwide citation)

A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondroc ...


3
Charles A Vacanti, Joseph P Vacanti, Martin P Vacanti: Guided development and support of hydrogel-cell compositions. University of Massachusetts, The Children&apos s Medical Center Corporation, Fish & Richardson P C, January 9, 2001: US06171610 (169 worldwide citation)

The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hydrogel-cell composit ...


4
Joseph P Vacanti, Charles A Vacanti, Robert S Langer: Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure. Massachusetts Institute of Technology, Children s Medical Center Corporation, Arnall Golden & Gregory, April 7, 1998: US05736372 (168 worldwide citation)

Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces and bone are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an a ...


5
Charles A Vacanti, Joseph P Vacanti: Guided development and support of hydrogel-cell compositions. University of Massachusetts Medical Center, The Children s Medical Center Corporation, Fish & Richardson P C, February 22, 2000: US06027744 (101 worldwide citation)

The invention features a method for generating new tissue, the method including: obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hy ...


6
Charles A Vacanti, Yi Lin Cao, Robert S Langer, Joseph P Vacanti, Keith Paige, Joseph Upton: Tissue engineered tendons and ligaments. Massachusetts Institute of Technology, Cambridge Childern s Medical Center Corproration, Clark & Elbing, September 26, 2000: US06123727 (86 worldwide citation)

Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells is ...


7
Charles A Vacanti: Tissue re-surfacing with hydrogel-cell compositions. University of Massachusetts, Fish & Richardson P C, August 31, 1999: US05944754 (84 worldwide citation)

The invention provides compositions and methods for generating new tissue on a surface, e.g., a surface of damaged or lost tissue, of a structure or organ in a mammal, The methods involve applying a thin layer of a liquid hydrogel-cell composition to the surface; and allowing the liquid hydrogel-cel ...


8
Charles A Vacanti, Yi Lin Cao, Robert S Langer, Joseph P Vacanti, Keith Paige, Joseph Upton: Tissue engineered tendons and ligaments. Massachusetts Institute of Technology, Children s Medical Center Corporation, Clark & Elbing, Kristina Bieker Brady Ph D, January 11, 2005: US06840962 (56 worldwide citation)

Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells is ...


9
Linda Griffith Cima, Anthony Atala, Charles A Vacanti, Keith T Paige: Tissue formation by injecting a cell-polymeric solution that gels in vivo. Massachusetts Institute of Technology, Children&apos s Medical Center Corporation, Choate Hall & Stewart, May 4, 2004: US06730298 (27 worldwide citation)

Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histol ...


10
Martin P Vacanti, Charles A Vacanti: Biological scaffolding material. VBI Technologies L L C, Pabst Patent Group, January 15, 2008: US07319035 (15 worldwide citation)

The invention provides methods of generating a natural, living biological matrix that can serve as, or form a part of, a natural biological scaffold. The matrix is generated by incubating together biological cells and cellular debris. Any naturally occurring cell can be a biological cell included in ...