Ron Majocha, Charles A Marotta, Sayeeda Zain: Antibodies to A4 amyloid peptide. The McLean Hospital, University of Rochester, Sterne Kessler Goldstein & Fox, July 27, 1993: US05231000 (119 worldwide citation)

Monoclonal antibodies to a 28-mer peptide present within A4-amyloid are described. These antibodies exhibit unexpected specificity for amyloid plaque structures previously unrecognized in Alzheimer's disease brains. These monoclonal antibodies are useful as reagents for use in assays and imaging of ...

Charles A Marotta, Sayeeda Zain: In vitro method for screening for drugs that inhibit production or degradation of human A4-amyloid. The McLean Hospital Corporation, University of Rochester, Sterne Kessler Goldstein & Fox P L L C, August 20, 1996: US05547841 (35 worldwide citation)

The invention relates to an in vitro method of screening for drugs, potentially useful for treatment of Alzheimer's Disease. The method involves contacting a drug with a host transformed with a DNA construct which contains at least the DNA coding for human A4-amyloid peptide and overexpresses the pe ...

Charles A Marotta, Ronald E Majocha, Sudhir Agrawal: Reversal of .beta./A4 amyloid peptide induced morphological changes in neuronal cells by antisense oligonucleotides. The General Hospital Corporation, Hale and Dorr, September 23, 1997: US05670634 (6 worldwide citation)

The invention provides oligonucleotides that inhibit the expression of .beta./A4 peptide of Alzheimer's disease and Down's syndrome, and further provides methods for reversing morphological changes caused in neuronal cells by .beta./A4 peptide.