1
Cerami Anthony, Kawakami Masanobu: Anabolic activity modulator and uses thereof.. Univ Rockefeller, March 4, 1987: EP0212489-A2 (154 worldwide citation)

A modulator material is disclosed which has been isolated from macrophage cells that have been incubated with a stimulator material from an invasive stimulus. The modulator material comprises a protein that exhibits the ability to substantially completely suppress the activity of the anabolic enzyme ...


2
Cerami Anthony, Kawakami Masanobu: Antibody to a mediator activity composition and its use in a pharmaceutical composition.. Univ Rockefeller, March 7, 1984: EP0101681-A1 (116 worldwide citation)

Mediator substances exhibiting inhibitory effect upon anabolic enzyme activity in mammals, are prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and ...


3
Cerami Anthony, Ulrich Peter, Brownlee Michael: Method and agents for inhibiting protein aging.. Univ Rockefeller, May 20, 1987: EP0222313-A2 (57 worldwide citation)

The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of t ...


4
Cerami Anthony, Smart John, Brines Michael, Cerami Carla: Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin. Warren Pharmaceuticals, Cerami Anthony, Smart John, Brines Michael, Cerami Carla, The Kenneth S Warren Institute, sMULGREW John P, March 24, 2005: WO/2005/025606 (48 worldwide citation)

Methods for increasing the hematocrit of an individual while maintaining the tissue protective activities of endogenous erythropoietin through the administration of a pharmaceutical compound containing chemically modified long acting erythropoietin. Also disclosed are the new chemically modified lon ...


5
Brines Michael, Cerami Anthony, Ghezzi Pietro, Fiordaliso Fbio, Fratelli Maddalena, Leist Marcel, Nielsen Mette, Sager Thomas, Pedersen Lars Ostergaard, Gerwien Jens, Coleman Thomas: Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof. The Kenneth S Warren Institute, Brines Michael, Cerami Anthony, Ghezzi Pietro, Fiordaliso Fbio, Fratelli Maddalena, Leist Marcel, Nielsen Mette, Sager Thomas, Pedersen Lars Ostergaard, Gerwien Jens, Coleman Thomas, CORUZZI Laura A, November 11, 2004: WO/2004/096148 (45 worldwide citation)

The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one &bgr;c Receptor. These compounds ...


6
Nielsen Jacob, Pedersen Jan Torleif, Gerwien Jens, Bay Katrine, Pedersen Lars Ostergaard, Leist Marcel, Geist Marie Aavang, Kallunki Pekka, Christensen Soren, Sager Thomas, Brines Michael, Cerami Anthony, Cerami Carla: Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs. The Kenneth S Warren Institute, H Lundbeck, CORUZZI Laura A, January 8, 2004: WO/2004/003176 (44 worldwide citation)

Methods and compositions are provided for protecting or enhancing a responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an recom ...


7
Brines Michael, Cerami Anthony, Hand Carla Cerami, Xie Qiao Wen, Christensen Soren, Foldager J, Vlabjorn M H, Theusen A H, Pedersen M, Munk M: Novel carbamylated epo and method for its production. The Kenneth S Warren Institute, Brines Michael, Cerami Anthony, Hand Carla Cerami, Xie Qiao Wen, Lundbeck H, Christensen Soren, Foldager J, Vlabjorn M H, Theusen A H, Pedersen M, Munk M, HAMBLE Frederick J, February 9, 2006: WO/2006/014466 (37 worldwide citation)

The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with ...


8
Ulrich Peter C, Cerami Anthony: Inhibitors of nonenzymatic cross-linking.. Univ Rockefeller, May 24, 1989: EP0316852-A2 (24 worldwide citation)

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises ; an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the ca ...


9
Cerami Anthony, Beutler Bruce, Wolpe Stephen D: Macrophage-derived inflammatory mediator (mip-1alpha and mip-1beta).. Univ Rockefeller, April 5, 1989: EP0310136-A2 (21 worldwide citation)

An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when ...


10
Brines Michael, Cerami Anthony, Cerami Carla: Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs. The Kenneth S Warren Institute, Brines Michael, Cerami Anthony, Cerami Carla, CORRUZZI Laura A, January 15, 2004: WO/2004/004656 (12 worldwide citation)

Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the inflammation, by systemic or local administration of a composition comprising a tissue protective cytokine. The i ...