1
Cato T Laurencin, Jessica Devin, Muhammed Attawia: Polymeric-hydroxyapatite bone composite. Massachusetts Institute of Technology, Arnall Golden & Gregory, May 6, 1997: US05626861 (137 worldwide citation)

A method for the fabrication of three-dimensional macroporous polymer matrices for use as bone graft or implant material was developed. The composites are formed from a mixture of biodegradable, biocompatible polymer and hydroxyapatite (HA), a particulate calcium phosphate ceramic. The method leaves ...


2
Cato T Laurencin, Jessica Devin, Muhammed Attawia: Polymeric-hydroxyapatite bone composite. Massachusetts Institute of Technology, Arnall Golden & Gregory, June 16, 1998: US05766618 (125 worldwide citation)

A method for the fabrication of three-dimensional macroporous polymer matrices for use as bone graft or implant material was developed. The composites are formed from a mixture of biodegradable, biocompatible polymer and hydroxyapatite (HA), a particulate calcium phosphate ceramic. The method leaves ...


3
Robert S Langer, Abraham J Domb, Cato T Laurencin: Controlled drug delivery high molecular weight polyanhydrides. Massachusetts Institute of Technology, Kilpatrick & Cody, December 19, 1989: US04888176 (104 worldwide citation)

A bioerodible controlled drug release device is produced as a homogeneous polymeric matrix from a high molecular weight polyanhydride and a suitable biologically active substance. The high molecular weight polyanhydride is defined by a molecular weight greater than 20,000 and an intrinsic viscosity ...


4
Tobin N Gerhart, Cato T Laurencin, Abraham J Domb, Robert S Langer, Wilson C Hayes: Bioerodible polymers for drug delivery in bone. Massachusetts Institute of Technology, Kilpatrick & Cody, February 15, 1994: US05286763 (71 worldwide citation)

Bioerodible polymers which degrade completely into nontoxic residues over a clinically useful period of time, including polyanhydrides, polyorthoesters, polyglycolic acid, polylactic acid, and copolymers thereof, are used for the delivery of bioactive agents, including antibiotics, chemotherapeutic ...


5
Cato T Laurencin, Lakshmi Sreedharan Nair, Subhabrata Bhattacharyya, Harry R Allcock, Jared D Bender, Paul W Brown, Yaser E Greish: Polymeric nanofibers for tissue engineering and drug delivery. June 26, 2007: US07235295 (62 worldwide citation)

Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be fo ...


6
Cato T Laurencin, Frank K Ko: Hybrid nanofibril matrices for use as tissue engineering devices. Drexel University, Licata & Tyrrell P C, February 10, 2004: US06689166 (47 worldwide citation)

Tissue engineering devices with enhanced cell adhesion, cell proliferation and directional growth are provided which are prepared from nonwoven nanofibril matrices.


7
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julie Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Arnall Golden & Gregory, May 13, 1997: US05629009 (39 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


8
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julianne Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Kilpatrick & Cody, October 18, 1994: US05356630 (37 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


9
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julianne Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 13, 1996: US05545409 (30 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


10
Cato T Laurencin, Saadiq El Amin, Archel M A Ambrosio, Shawn R Pucher, Harry R Allcock: Poly(organophosphazene) matrices for bone replacement. The Penn State Research Foundation, Massachusetts Institute of Technology, Arnall Golden & Gregory, May 22, 2001: US06235061 (15 worldwide citation)

A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a preferred embodiment, the poly(organophosphazene) includes between 10 and 90% hydrolytically unstable si ...