1
Charles R Cantor, Marek Przetakiewicz, Cassandra L Smith, Takeshi Sano: Method for replicating an array of nucleic acid probes. Trustees of Boston University, James Baker & Botts L Remenick, August 18, 1998: US05795714 (165 worldwide citation)

The invention relates to the replication of probe arrays and methods for replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- ...


2
Dong Jing Fu, Charles R Cantor, Hubert Köster, Cassandra L Smith: Solid phase sequencing of double-stranded nucleic acids. Boston University, Sequenom, Stephanie L Seidman, Paula Schaeneck, Heller Ehrman White & McAuliffe, August 20, 2002: US06436635 (107 worldwide citation)

This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic ac ...


3
Takeshi Sano, Charles R Cantor, Cassandra L Smith: Immuno-polymerase chain reaction system for antigen detection. The Regents of the University of California, Richard Aron Osman, September 9, 1997: US05665539 (77 worldwide citation)

A novel system and method for sensitive antigen detection. The system utilizes immuno-polymerase chain reaction in which a specific biotinylated nucleic acid molecule is used as the marker. The biotinylated marker is attached to antigen-antibody complex through a streptavidin-protein A chimeric prot ...


4
Cassandra L Smith, Ron Yaar, Przemyslaw Szafranski, Charles R Cantor: Nucleic acid detection methods. Trustees of Boston University, James Baker & Botts L Remenick, May 19, 1998: US05753439 (73 worldwide citation)

The invention relates to methods for rapidly determining the sequence and/or length a target sequence. The target sequence may be a series of known or unknown repeat sequences which are hybridized to an array of probes. The hybridized array is digested with a single-strand nuclease and free 3'-hydro ...


5
Charles R Cantor, Takashi Ito, Cassandra L Smith: DNA purification by triplex-affinity capture and affinity capture electrophoresis. The Regents of the University of California, Flehr Hohbach Test Albritton & Herbert, January 9, 1996: US05482836 (59 worldwide citation)

The invention provides a method for purifying or isolating double stranded DNA intact using triple helix formation. The method includes the steps of complexing an oligonucleotide and double stranded DNA to generate a triple helix and immobilization of the triple helix on a solid phase by means of a ...


6
Charles R Cantor, Marek Przetakiewicz, Takeshi Sano, Cassandra L Smith: Positional sequencing by hybridization. The Trustees of Boston University, Stephanie L Heller Ehrman White & McAuliffe Seidman, December 28, 1999: US06007987 (45 worldwide citation)

This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That information can b ...


7
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, James Remenick, Baker & Botts L, October 1, 1996: US05561043 (45 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


8
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, Univ of Mass Medical Center, Medlen & Carroll, October 12, 1999: US05965133 (19 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


9
Dong Jing Fu, Charles R Cantor, Hubert Köster, Cassandra L Smith: Solid phase sequencing of double-stranded nucleic acids. Sequenom, The Trustees of Boston University, Fish & Richardson P C, Stephen Seidman, Frank J Miskiel, January 31, 2006: US06991903 (14 worldwide citation)

Methods for detecting and sequencing of target double-stranded nucleic acid molecules, nucleic acid probes and arrays of probes useful in these methods, and kits and systems that contain these probes are provided. The methods involve hybridizing the nucleic acids or nucleic acids which represent com ...


10
Takeshi Sano, Charles R Cantor, Sandor Vajda, Gabriel O Reznik, Cassandra L Smith, Mark W Pandori: Streptavidin mutants. February 8, 2000: US06022951 (13 worldwide citation)

The present invention relates to streptavidin proteins and peptides having a altered physical properties such as an increased stability or increased or decreased affinity for binding biotin. The invention also relates to methods for the detection, identification, separation and isolation of targets ...