1
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 17, 1996: US05585089 (1552 worldwide citation)

Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunog ...


2
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, June 25, 1996: US05530101 (1356 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


3
Cary L Queen, Man Sung Co, William P Schneider, Nicholas F Landolfi, Kathleen L Coelingh, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend & Townsend & Crew, December 2, 1997: US05693762 (1197 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


4
Cary L Queen, Harold E Selick: Humanized immunoglobulins and methods of making the same. Protein Design Labs, Townsend and Townsend and Crew, January 30, 2001: US06180370 (811 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized i ...


5
Cary L Queen, William P Schneider, Harold E Selick: Polynucleotides encoding improved humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 2, 1997: US05693761 (692 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


6
Cary L Queen: Apparatus and method for comparing data groups. Advanced Software, Hecker & Harriman, February 21, 1989: US04807182 (210 worldwide citation)

Method and apparatus for comparing original and modified versions of a document. The system of the present invention utilizes a hash number generator CPU to generate hash numbers for lines and sentences contained in the documents. Matching hash numbers are defined as anchorpoints and stored in an an ...


7
Man Sung Co, David A Scheinberg, Cary L Queen: Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region. Protein Design Labs, Sloan Kettering Cancer Center, Townsend and Townsend and Crew, February 3, 1998: US05714350 (203 worldwide citation)

The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region a ...


8
Man Sung Co, David A Scheinberg, Cary L Queen: Antibodies with increased binding affinity. Protein Design Labs, Memorial Sloan Kettering Cancer Center, Townsend & Townsend & Crew, February 26, 2002: US06350861 (176 worldwide citation)

The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region a ...


9
Man Sung Co, David A Scheinberg, Cary L Queen: Increasing antibody affinity by altering glycosylation of immunoglobulin variable region. Protein Design Labs, Memorial Sloan Kettering Cancer Center, Townsend and Townsend and Crew, August 23, 2005: US06933368 (85 worldwide citation)

The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region a ...


10
Maximiliano Vasquez, Nicholas F Landolfi, Naoya Tsurushita, Cary L Queen: Humanized antibodies to &ggr;-interferon. Protein Design Labs, Townsend and Townsend and Crew, December 11, 2001: US06329511 (63 worldwide citation)

The invention provides humanized immunoglobulins that bind to and neutralize &ggr;-interferon. The antibodies are useful for treatment of diseases of the immune system, particularly autoimmune diseases.