1
Eliana Saxon, Carolyn Bertozzi: Chemoselective ligation. The Regents of the University of California, Paula A Bordan, Carol L Francis, Boziecevic Field & Francis, May 27, 2003: US06570040 (49 worldwide citation)

The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulti ...


2
Carolyn Bertozzi, Kevin J Yarema, Lara K Mahal: Glycoconjugates and methods. The Regents of the University of California, Richard Aron Osman, June 13, 2000: US06075134 (47 worldwide citation)

Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (i ...


3
Carolyn Bertozzi, Ravindranath Mukkamala, Oing Chen, Hopin Hu, Dominique Baude: Biomimetic hydrogel materials. The Regents of the University of California, Hana Verny, April 22, 2003: US06552103 (44 worldwide citation)

Novel biomimetic hydrogel materials and methods for their preparation. Hydrogels containing acrylamide-functionalized carbohydrate, sulfoxide, sulfide or sulfone copolymerized with a hydrophilic or hydrophobic copolymerizing material selected from the group consisting of an acrylamide, methacrylamid ...


4
Carolyn Bertozzi, Kevin J Yarema, Lara K Mahal: Glycoconjugates and methods. The Regents of the University of California, Hana Very, October 1, 2002: US06458937 (44 worldwide citation)

Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (i ...


5
Eliana Saxon, Carolyn Bertozzi: Chemoselective ligation. The Regents of the University of California, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, October 17, 2006: US07122703 (36 worldwide citation)

The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulti ...


6
Carolyn Bertozzi, Ravindranath Mukkamala, Qing Chen, Hopin Hu, Dominique Baude: Biomimetic hydrogel materials. The Regents of the University of California, Hana Verny, August 22, 2000: US06107365 (32 worldwide citation)

Novel biomimetic hydrogel materials and methods for their preparation. Hydrogels containing acrylamide-functionalized carbohydrate, sulfoxide, sulfide or sulfone copolymerized with a hydrophilic or hydrophobic copolymerizing material selected from the group consisting of an acrylamide, methacrylamid ...


7
Jon O Nagy, Wayne R Spevak, Falguni Dasgupta, Carolyn Bertozzi: Inhibition of selectin binding. The Regents of the University of California, Gladys H Monroy, Robert K Cerpa, Morrison & Foerster, October 5, 1999: US05962422 (28 worldwide citation)

This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composit ...


8
Steven D Rosen, Carolyn Bertozzi: Sulfated disaccharide inhibitors of selectins, methods for synthesis and therapeutic use. The Regents Of The University Of California, Bret E Bozicevic Field&Francis Field, November 2, 1999: US05977080 (21 worldwide citation)

Sulfated disaccharides characterized by the ability to inhibit the binding of selectin to its physiologically-relevant ligand are disclosed. Included are efficient and inexpensive methods for producing the sulfated disaccharides, and methods for their therapeutic use and in in vivo and in vitro assa ...


9
Carolyn Bertozzi, Kevin J Yarema, Lara K Mahal: Glycoconjugates and methods. The Regents of the University of California, Peters Verny Jones Schmitt & Aston, David J Aston, August 30, 2005: US06936701 (14 worldwide citation)

Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (i ...


10
Isaac S Carrico, Brian L Carlson, Peng Wu, Carolyn Bertozzi: Aldehyde tags, uses thereof in site-specific protein modification. The Regents of the University of California, Carol L Francis, Bozicevic Field & Francis, July 26, 2011: US07985783 (8 worldwide citation)

The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The alde ...