1
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Roseman, January 17, 1995: US05382657 (204 worldwide citation)

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in v ...


2
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-inerferon conjugates. F Hoffmann La Roche, wen hongyan, March 24, 1999: CN97105433

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.


3
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. F Hoffmann La Roche, WEN HONGYAN, February 18, 1998: CN97105434

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.


4
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. F Hoffmann La Roche, LIU YUANJIN WANG YANG, July 6, 1994: CN93116479

The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.