1
Carini David John, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles.. Du Pont, January 20, 1988: EP0253310-A2 (316 worldwide citation)

Substituted imidazoles such as are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.


2
Carini David John, Wong Pancras Chor Bun, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids.. Du Pont, July 19, 1989: EP0324377-A2 (169 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


3
Carini David John, Wells Gregory James, Duncia John Jonas Vytautas: Substituted pyrrole, pyrazole and triazole angiotensin ii antagonists.. Du Pont, July 12, 1989: EP0323841-A2 (153 worldwide citation)

Substituted pyrroles, pyrazoles and triazoles of the formula and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.


4
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Pharmaceutical compositions comprising angiotensin ii receptor blocking imidazoles and diuretics. Du Pont, September 25, 1996: EP0733366-A2 (17 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


5
Carini David John, Duncia John Jonas Vytautus: Combination beta-blocking/angiotensin ii blocking antihypertensives.. Du Pont, August 8, 1990: EP0380959-A1 (10 worldwide citation)

Imidazole compounds of the formula (I) which have angiotensin II antagonizing properties as well as beta -adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of congestive heart failure.


6
Carini David John: Angiotensin-11 receptor blocking cycloalkylbenzylimidazoles. Du Pont Merck Pharma, June 1, 1994: GB2272899-A (10 worldwide citation)

Novel cycloalkylbenzylimidazoles of Formula (I), where X is a cycloalkenyl group substitutes at the alpha position by a carboxyl or tetrazolyl group. These compounds are useful angiotensin II antagonists.


7
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists.. Du Pont, March 31, 1993: EP0533840-A1 (4 worldwide citation)

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hyd roxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl )imidazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure ...


8
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists. Ei Du Pont de Nemours And Company, CHRISTENBURY Lynne M, January 9, 1992: WO/1992/000067 (1 worldwide citation)

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure, ...


9
Fevig John Matthew, Kettner Charles Adrian, Lee Sheng Lian O, Carini David John: Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes. Du Pont Merck Pharma, February 14, 1996: EP0696199-A1

This invention relates to Novel alpha -aminoboronic acid and corresponding peptide analogs of formula (I) are disclosed.


10
Ardecky Robert John, Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Derives de substitution aryliques dimidazoles a noyaux fusionnes, Fused-ring aryl substituted imidazoles. E I Du Pont de Nemours And Company, SIM & MCBURNEY, December 31, 1990: CA2059000

(see fig. I)Substituted imidazoles of formula (I) are useful as angiotensin II blockers. These compounds have activity in treatinghypertension and congestive heart failure.