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Caprathe Bradley William, Gogliotti Rocco Dean, Jennings Rex Allen, Simons Lloyd Jerome: Piperidine derivatives. Pfizer Products, Caprathe Bradley William, Gogliotti Rocco Dean, Jennings Rex Allen, Simons Lloyd Jerome, FULLER Grover F Jr, February 28, 2008: WO/2008/023258 (23 worldwide citation)

The invention relates to compounds of Formula (I) and pharmaceutically acceptable acid addition salts thereof, wherein *, X1, X2, R5A, R5B, R6, R7, and R8 are as defined jn the specification; pharmaceutical compositions; therapeutic combinations; uses in the manufacture of medicaments; and methods o ...


2
Caprathe Bradley William, Smith Sarah Jane, Jaen Juan Carlos, Wise Lawrence David: Substituted cyclohexanols as central nervous system agents.. Warner Lambert Co, June 12, 1991: EP0431580-A2 (13 worldwide citation)

Substituted cyclohexanols and cyclohexylamines and derivatives thereof of the formula I as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive ag ...


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Caprathe Bradley William, Jaen Juan Carlos, Wise Lawrence David: Substituted 2-aminothiazoles as dopaminergic agents.. Warner Lambert Co, December 13, 1989: EP0345533-A1 (6 worldwide citation)

Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well ...


5
Caprathe Bradley William, Jaen Juan Carlos, Wise Lawrence David: Thiazolo not f -fused hexahydroquinoline derivatives as dopaminergic agents. Warner Lambert Co, March 23, 1988: EP0260642-A2 (4 worldwide citation)

Hetero [f] fused carbocyclic pyridines of the formula I are described, as well as processes for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and anti ...


6
Caprathe Bradley William, Smith Sarah Jane, Jaen Juan Carlos, Wise Lawrence David: Substituted cyclohexenes as central nervous system agents.. Warner Lambert Co, June 12, 1991: EP0431579-A2 (3 worldwide citation)

Substituted cyclohexenes of formula I are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperp ...


7
Caprathe Bradley William, Downing Dennis Michael, Jaen Juan Carlos, Johnson Stephen Joseph, Smith Iii William John, Wise Lawrence David, Wright Jonathan, Wustrow David Juergen: 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents.. Warner Lambert Co, June 9, 1993: EP0545095-A1 (2 worldwide citation)

1,3-Substituted cycloalkenes and cycloalkanes of Formula I Z-CH2-Y I wherein Z is Y is wherein the meaning of R and m are provided in the description, are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and a ...


8
Caprathe Bradley William, Gilmore John Lodge, Harter William Glen, Hays Sheryl Jeanne, Knapp Kristen Michele, Kostlan Catherine Rose, Lunney Elizabeth Ann, Para Kimberly Suzanne, Galatsis Paul, Thomas Anthony Jerome: Succinamide inhibitors of interleukin-1beta converting enzyme. Warner Lambert Co, BASF, March 14, 2001: EP1082127-A1 (2 worldwide citation)

The present invention provides compounds of Formula (I), pharmaceutical compositions comprising a compound of Formula (I), and methods of treatment of stroke; inflammatory diseases such as rheumatoid arthritis or inflammatory bowel disease; septic shock; reperfusion injury; Alzheimer's disease; shig ...


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Albrecht Hans P, Allen Hamish John, Brady Kenneth Dale, Caprathe Bradley William, Gilmore John Lodge, Harter William Glen, Hays Sheryl Jeanne, Kostlan Catherine Rose, Lunney Elizabeth Ann, Para Kimberly Suzanne, Thomas Anthony Jerome, Walker Nigel: (b) Converting enzyme. Warner Lambert Co, BASF, August 4, 1999: EP0932598-A1 (2 worldwide citation)

The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have formula (I). This invention also relates to a method of treatment of stroke, inflammatory diseases, reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acc ...


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Guo Chuangxing, Augelli Szafran Corinne E, Barta Nancy Sue, Bender Steven Lee, Bigge Christopher Franklin, Caprathe Bradley William, Chatterjee Arindam, Deal Judith, Dong Liming, Fay Lorraine Kathleen, Hou Xinjun, Hudack Raymond Andrew Jr: Heterobicycles fkbp-ligands. Agouron Pharma, June 2, 2004: EP1423119-A1

Diazabicyclo[3.3.1]nonane derivatives that inhibit the peptidyl-prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described for treating neurological disorders. Also described are compounds useful for preparing such inhibitors.