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Wallace John L, Cirino Giuseppe, Caliendo Giuseppe, Sparatore Anna, Santagada Vincenzo, Fiorucci Stefano: Derivatives of 4- or 5-aminosalicylic acid. Antibe Therapeutics, Wallace John L, Cirino Giuseppe, Caliendo Giuseppe, Sparatore Anna, Santagada Vincenzo, Fiorucci Stefano, BENNETT JONES, November 30, 2006: WO/2006/125293 (42 worldwide citation)

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bo ...


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Wallace John L, Cirino Giuseppe, Caliendo Giuseppe, Sparatore Anna, Santagada Vincenzo, Fiorucci Stefano: Derivatives of 4-or 5-aminosalicylic acid. Antibe Therapeutics, Wallace John L, Cirino Giuseppe, Caliendo Giuseppe, Sparatore Anna, Santagada Vincenzo, Fiorucci Stefano, BENNETT JONES, November 30, 2006: WO/2006/125295 (4 worldwide citation)

The present invention provides new derivatives of 4-or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4-or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowe ...


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Wallace John L, Cirino Giuseppe, Santagada Vincenzo, Caliendo Giuseppe: Salts of trimebutine and n-desmethyl trimebutine. Antibe Therapeutics, Wallace John L, Cirino Giuseppe, Santagada Vincenzo, Caliendo Giuseppe, BENNETT JONES, December 13, 2007: WO/2007/140611 (2 worldwide citation)

Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by a ...


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Wallace John L, Cirino Giuseppe, Santagada Vincenzo, Caliendo Giuseppe: Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs. Antibe Therapeutics, Wallace John L, Cirino Giuseppe, Santagada Vincenzo, Caliendo Giuseppe, BENNETT JONES, January 24, 2008: WO/2008/009127 (1 worldwide citation)

The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce nov ...


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Wallace John L, Sparatore Anna, Cirino Giuseppe, Caliendo Giuseppe, Santagada Vincenzo, Fiorucci Stefano: Derivatives of 4-or 5-aminosalicylic acid. Antibe Therapeutics, February 6, 2008: EP1883645-A1

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bo ...


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Cirino Giuseppe, Caliendo Giuseppe, Santagada Vincenzo, Fiorucci Stefano, Wallace John L, Sparatore Anna: Derivatives of 4-or 5-aminosalicylic acid. Antibe Therapeutics, zhangmin, August 6, 2008: CN200680025156

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bo ...


10
Wallace John L, Cirino Giuseppe, Santagada Vincenzo, Caliendo Giuseppe: Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs. Antibe Therapeutics, May 13, 2009: EP2057139-A1

Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.