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Buckman Brad O, Wang Guangyi, Beigelman Leonid, Stoycheva Antitsa Dimitrova: Novel inhibitors of hepatitis c virus replication. Intermune, Buckman Brad O, Wang Guangyi, Beigelman Leonid, Stoycheva Antitsa Dimitrova, MALLON Joseph J, November 5, 2009: WO/2009/134616 (10 worldwide citation)

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibr ...


2
Mohan Raju, Buckman Brad O, Morrissey Michael M, Chitty Andrew I, Martin John T: Apparatus and process for multiple chemical reactions. Berlex Lab, August 26, 1998: EP0859661-A1 (2 worldwide citation)

Multiple chemical reactions are performed in a plurality of reaction vessels mounted in inlets in a manifold valve block. The manifold valve block is connected to a channel block which is utilized in conjunction with a solvent delivery system as part of the reaction cycle. The solvent fluid is drain ...


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Bauman John G, Buckman Brad O, Ghannam Ameen F, Hesselgesser Joseph E, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howard P, Wei Guo Ping, Xu Wei, Zheng Wei: Piperazine derivatives and their use as anti-inflammatory agents. Schering, March 29, 2000: EP0988292-A2 (1 worldwide citation)

This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.


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BUCKMAN Brad O, NICHOLAS John B, EMAYAN Kumaraswamy, SEIWERT Scott D: [fr] ANTAGONISTES DES RÉCEPTEURS DACIDE LYSOPHOSPHATIDIQUE, [en] LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS. BUCKMAN Brad O, NICHOLAS John B, EMAYAN Kumaraswamy, SEIWERT Scott D, INTERMUNE, HART Daniel, February 21, 2013: WO/2013/025733 (1 worldwide citation)

[en] Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provide ...


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Bauman John G, Buckman Brad O, Hesselgasser Josep E, Ghannam Ameen F, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howarfd P, Wei Gua Ping, Xu Wie, Zheng Wie, Shaw Kenneth J, Zuchun Zhao: Piperazine derivatives and their use as anti-inflammatory agents. Schering, November 6, 2002: EP1254899-A2

This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.


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BUCKMAN BRAD O, EMAYAN KUMAR, ISLAM IMADUL, MAY KAREN, BRYANT JUDI, MOHAN RAJU, WEST CHRISTOPHER L, YUAN SHENDONG: [fr] Dérivés de lacid phosphonic comme inhibiteurs de Plasma Carboxypeptidase B, [de] Phosphonsäure Derivaten als Plasma Carboxypeptidase B Inhibitoren, [en] Phosphonic acid as Plasma Carboxypeptidase B Inhibitors. BAYER SCHERING PHARMA, July 7, 2010: EP2204373-A1

[en] Compounds of the following formula (II), for example: wherein R 1 , R 2 , R 3 , and R 4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes fo ...


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Bauman John G, Buckman Brad O, Ghannam Ameen F, Hesselgesser Joseph E, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howard P, Wei Guo Ping, Xu Wei, Zheng Wei, Shaw Kenneth J, Zuchun Zhao: Derives de piperazine et leur utilisation en tant quagents anti-inflammatoires, Piperazine derivatives and their use as anti-inflammatory agents. Schering Aktiengesellschaft, Schering Aktiengesellschaft, MARKS & CLERK, December 17, 1998: CA2293382

The invention is directed to acyl piperazine derivatiaves of formula Ia (see formula Ia) which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory di ...


8
Buckman Brad O, Davey David D, Guilford William J, Morrissey Michael M, Ng Howard P, Phillips Gary B, Wu Shung C, Xu Wei: Derives de benzamidine et utilisation de ces derives en tant quanticoagulants, Benzamidine derivatives their preparation and their use as anti-coagulants. Berlex Laboratories, Berlex Laboratories, BERESKIN & PARR, September 19, 1996: CA2214685

This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity. Accord ...


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Buckman Brad O, Emayan Kumar, Islam Imadul, May Karen, Bryant Judi, Mohan Raju, West Christopher, Yuan Shendong: Plasma carboxypeptidase b inhibitors. Schering, January 19, 2005: EP1497300-A2

Compounds of the following formula (I), for example: (1), wherein R, R, R, and R are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizi ...