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Buckman Brad O, Emayan Kumar, Islam Imadul, May Karen, Bryant Judi, Mohan Raju, West Christopher, Yuan Shendong: Plasma carboxypeptidase b inhibitors. Schering Aktiengesellschaft, Buckman Brad O, Emayan Kumar, Islam Imadul, May Karen, Bryant Judi, Mohan Raju, West Christopher, Yuan Shendong, sSHAW Melissa A, October 2, 2003: WO/2003/080631

Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthe ...


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Bauer Shawn, Mohan Raju, Shaw Kenneth J, Wu Qingyu, Ye bin, Buckman Brad O, Ghannam Ameen, Griedel Brian D, Khim Seock Kyu, Zhao Zuchun: Menthol substituted antithrombotic pai-1 inhibitors. Schering Aktiengesellschaft, Bauer Shawn, Mohan Raju, Shaw Kenneth J, Wu Qingyu, Ye bin, Buckman Brad O, Ghannam Ameen, Griedel Brian D, Khim Seock Kyu, Zhao Zuchun, SHAW Melissa A, October 2, 2003: WO/2003/080564

This invention is directed to menthol-substituted compounds and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention relates to pharmaceutical compositions and their pharmaceutica ...


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Bryant Judi A, Buckman Brad O, Islam Imadul, Mohan Raju, Morrissey Michael M, Wei Guo Ping, Xu Wei, Yuan Shendong: (naphthaline) Platelet adenosine diphosphate receptor antagonists. Schering Aktiengesellschaft, Bryant Judi A, Buckman Brad O, Islam Imadul, Mohan Raju, Morrissey Michael M, Wei Guo Ping, Xu Wei, Yuan Shendong, ZELANO Antony J Millen White Zelano Arlington Courthouse Plaza 1 2200 Clarendon Boulevard Suite 1400 Arlington VA 22201, December 12, 2002: WO/2002/098856

Compounds of the following formula (I): where a, b, R?1¿, R?2¿, R?3¿, R?4¿ and R?6¿ are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for sy ...


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Mohan Raju, Buckman Brad O, Morrissey Michael M, Chitty Andrew I, Martin John T: Apparatus and process for multiple chemical reactions. Berlex Laboratories, Mohan Raju, Buckman Brad O, Morrissey Michael M, Chitty Andrew I, Martin John T, MOSES John R, March 27, 1997: WO/1997/010896

Multiple chemical reactions are performed in a plurality of reaction vessels (12) mounted in inlets in a manifold valve block (30). The manifold valve block (30) is connected to a channel block (34) which is utilized in conjunction with a solvent delivery system (21) as part of the reaction cycle. T ...


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Morrissey Michael M, Buckman Brad, Mohan Raju: Bicyclic pyrimidine derivatives and their use as anti-coagulants. Schering Aktiengesellschaft, February 26, 1998: WO/1998/007723

This invention is directed to bicyclic pyrimidine derivatives which are useful as anti-coagulants, of formulae (I) and (II), wherein A is -O-, -N(R?5¿)-, or -S(O)¿n?- (where n is 0, 1 or 2); Z?1¿ and Z?2¿ are independently -O-, -N(R?5¿)- or -OCH¿2?-. This invention is also directed to pharmaceutical ...


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Morrissey Michael M, Buckman Brad, Mohan Raju: Purine derivatives and their use as anti-coagulants. Schering Aktiengesellschaft, February 26, 1998: WO/1998/007725

This invention is directed to purine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.


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Bauman John G, Buckman Brad O, Ghannam Ameen F, Hesselgesser Joseph E, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howard P, Wei Guo Ping, Xu Wei, Zheng Wei: Piperazine derivatives and their use as anti-inflammatory agents. Schering Aktiengesellschaft, December 17, 1998: WO/1998/056771

This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.


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Buckman Brad, Dole William P, Kawai Kohichi, Morser Michael John, Nagashima Mariko, Vergona Ronald, Wang Yi Xin: Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci. Bayer Schering Pharma Aktiengesellschaft, Buckman Brad, Dole William P, Kawai Kohichi, Morser Michael John, Nagashima Mariko, Vergona Ronald, Wang Yi Xin, LARSON Jacqueline S, October 26, 2006: WO/2006/113247

This invention relates to TAFI inhibitors and their use to enhance myocardial reperfusion and facilitate percutaneous coronary intervention (PCI) in the treatment of acute ST elevation myocardial infarction (STEMI).


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