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Buckman Brad O, Wang Guangyi, Beigelman Leonid, Stoycheva Antitsa Dimitrova: Novel inhibitors of hepatitis c virus replication. Intermune, Buckman Brad O, Wang Guangyi, Beigelman Leonid, Stoycheva Antitsa Dimitrova, MALLON Joseph J, November 5, 2009: WO/2009/134616 (10 worldwide citation)

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibr ...


12
BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D: INHIBITEURS PROLINE SUBSTITUÉE DE RÉPLICATION DU VIRUS DE LHÉPATITE C, SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION. INTERMUNE, BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D, MILLER Kimberly J, March 29, 2012: WO/2012/040242 (10 worldwide citation)

The embodiments provide compounds of the general Formulae I, la, II,IIa,III, IIIa, Illb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods ...


13
BUCKMAN Brad, SEREBRYANY Vladimir, NICHOLAS John B, SEIWERT Scott: NOUVEAUX INHIBITEURS MACROCYCLIQUES DE LA RÉPLICATION DU VIRUS DE LHÉPATITE C, NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION. INTERMUNE, BUCKMAN Brad, SEREBRYANY Vladimir, NICHOLAS John B, SEIWERT Scott, HART Daniel, April 26, 2012: WO/2012/054874 (9 worldwide citation)

The embodiments provide compounds of the general Formulae I, la, II, Ila, IIΙ, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis ...


14
BUCKMAN BRAD: Therapeutic antiviral peptides. INTERMUNE, Mallon Joseph J, April 7, 2011: WO/2011/041551 (9 worldwide citation)

The invention relates to macrocyclic compounds of Formula 1 (in which the variables are as defined herein) for use in the treatment of hepatitis C virus. Therapeutic methods, medicaments and dosage forms related thereto are also disclosed.


15
BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D: NOUVEAUX INHIBITEURS DE LA RÉPLICATION DU VIRUS DE LHÉPATITE C, NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION. INTERMUNE, BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D, MILLER Kimberly J, March 22, 2012: WO/2012/037259 (9 worldwide citation)

The invention relates to macrocyclic compounds of Formula e I. (in which the variables are as defined herein) for use in the treatment of hepatitis C virus. Therapeutic methods, medicaments and dosage forms related thereto are also disclosed.


16
Mohan Raju, Buckman Brad O, Morrissey Michael M, Chitty Andrew I, Martin John T: Apparatus and process for multiple chemical reactions. Berlex Lab, August 26, 1998: EP0859661-A1 (2 worldwide citation)

Multiple chemical reactions are performed in a plurality of reaction vessels mounted in inlets in a manifold valve block. The manifold valve block is connected to a channel block which is utilized in conjunction with a solvent delivery system as part of the reaction cycle. The solvent fluid is drain ...


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Bauman John G, Buckman Brad O, Ghannam Ameen F, Hesselgesser Joseph E, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howard P, Wei Guo Ping, Xu Wei, Zheng Wei: Piperazine derivatives and their use as anti-inflammatory agents. Schering, March 29, 2000: EP0988292-A2 (1 worldwide citation)

This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.


18
Morrissey Michael M, Buckman Brad, Mohan Raju: Bicyclic pyrimidine derivatives and their use as anti-coagulants. Schering, June 16, 1999: EP0922045-A1 (1 worldwide citation)

This invention is directed to bicyclic pyrimidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity ...


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BUCKMAN Brad O, NICHOLAS John B, EMAYAN Kumaraswamy, SEIWERT Scott D: [fr] ANTAGONISTES DES RÉCEPTEURS DACIDE LYSOPHOSPHATIDIQUE, [en] LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS. BUCKMAN Brad O, NICHOLAS John B, EMAYAN Kumaraswamy, SEIWERT Scott D, INTERMUNE, HART Daniel, February 21, 2013: WO/2013/025733 (1 worldwide citation)

[en] Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provide ...


20
Bauman John G, Buckman Brad O, Hesselgasser Josep E, Ghannam Ameen F, Horuk Richard, Islam Imadul, Liang Meina, May Karen B, Monahan Sean D, Morissey Michael M, Ng Howarfd P, Wei Gua Ping, Xu Wie, Zheng Wie, Shaw Kenneth J, Zuchun Zhao: Piperazine derivatives and their use as anti-inflammatory agents. Schering, November 6, 2002: EP1254899-A2

This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.