1
Paul O Zamora, Buck A Rhodes: Peptide-metal ion pharmaceutical preparation and method. Rhomed Incorporated, Deborah A Peacock, August 22, 1995: US05443816 (84 worldwide citation)

Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence


2
David R Crockford, Buck A Rhodes: Method and composition for cancer detection in humans. Nuc Med, University Patents, Paul J Cook, April 6, 1982: US04323546 (73 worldwide citation)

Anti human chorionic gonadotropin (anti-hCG) and/or anti human chorionic gonadotropin- beta subunit (anti-hCG-.beta.) labeled with Technetium-99M are/is administered to a human. The biodistribution of the labeled composition is monitored in order to determine whether the labeled composition accumula ...


3
Buck A Rhodes: Direct radiolabeling of antibodies and other proteins with technetium or rhenium. RhoMed Incorporated, Deborah A Peacock, April 7, 1992: US05102990 (67 worldwide citation)

Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the protein using Sn (II), or using othe ...


4
David R Crockford, Buck A Rhodes: Method for radiolabeling proteins with technetium-99m. Nuc Med, University Patents, Paul J Cook, January 3, 1984: US04424200 (57 worldwide citation)

Proteins are radiolabeled with technetium-99m in a reducing environment comprising buffered stannous chloride wherein the tin utilized to form the stannous chloride is non-oxidized, the buffered stannous chloride is purged of oxygen and the buffer comprises an alkali metal biphthalate and an alkali ...


5
Buck A Rhodes: Labeling proteins with 99m-Tc by ligand exchange. University Patents, Mason Kolehmainen Rathburn & Wyss, December 15, 1981: US04305922 (56 worldwide citation)

A new method for labeling proteins with 99m-technetium: (1) Start with any volume of technetium (pertechnetate and saline) solution and add 0.1 ml of stannous solution (stannous fluoride-acetate solution) per 15-20 ml of saline. The stannous ions will reduce the pertechnetate to technetium IV. (2) P ...


6
Scott W Burchiel, David R Crockford, Buck A Rhodes: Composition and method for cancer detection in humans. Serono Laboratories, University Patents, Paul J Cook, January 19, 1982: US04311688 (38 worldwide citation)

Antibody to anti human chorionic gonadotropin and/or antibody to anti human chorionic gonadotropin-beta subunit labeled with technetium-99m, iodine-123, iodine-125 or iodine-131 are/is administered to a human after the human has been administered anti-hCG and/or anti-hCG beta. The biodistribution of ...


7
Buck A Rhodes, Paul O Zamora: Direct labeling of antibodies and other protein with metal ions. RhoMed Incorporated, Deborah A Peacock, October 24, 1995: US05460785 (37 worldwide citation)

Proteins containing one or more dtsulfide bonds or monosulfides are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologtc conditions. Labeling is accomplished with a variety of metals, including radiometals, by using a reducing agent to reduce the dis ...


8
Buck A Rhodes: Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction. RhoMed Incorporated, Deborah A Peacock, January 7, 1992: US05078985 (35 worldwide citation)

Proteins are radiolabeled with radionuclides of technetium or rhenium by a process in which the disulfide bonds of the protein are first partially reduced with stannous salts or other disulfide reducing agents, all substances other than the desired reduced protein removed, by size exclusion chromato ...


9
Scott W Burchiel, Buck A Rhodes, David R Crockford: Radiolabeled antibody to anti-tumor associated antigen and process. Summa Medical Corporation, University Patents, Paul J Cook, September 18, 1984: US04472371 (34 worldwide citation)

Antibodies to human carcinoembryonic antigen (CEA), human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or other anti-TAAs, such as human ...


10
Scott W Burchiel, Buck A Rhodes, David R Crockford: Composition and method for detecting cancer with technetium labeled antibody fragments. Nuc Med, University Patents, Paul J Cook, October 23, 1984: US04478815 (34 worldwide citation)

F(ab').sub.2 or Fab fragments of antibodies to: (a) human chorionic gonadotropin (hCG), hCG alpha subunit, hCG beta subunit, or an hCG-like material; or (b) other tumor specific or tumor associated molecules, to include carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), human melanoma associat ...