1
Bruce E Maryanoff, Joseph F Gardocki: Anticonvulsant sulfamate derivatives. McNeil Lab, David J Levy, April 23, 1985: US04513006 (109 worldwide citation)

Sulfamates of the following formula (I): ##STR1## wherein X is O or CH.sub.2 and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compos ...


2
Michael J Costanzo, Bruce E Maryanoff: Anticonvulsant sorbopyranose sulfamates. McNeilab, Ralph R Palo, January 24, 1995: US05384327 (45 worldwide citation)

Sulfamate derivatives having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are as herein defined, have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, the present invent ...


3
Han Cheng Zhang, Bruce E Maryanoff, Hong Ye, Bruce R Conway, Keith Demarest: Substituted pyrrolines as kinase inhibitors. Janssen Pharmaceutica, Gabriel Lopez, Hal B Woodrow, January 17, 2006: US06987110 (44 worldwide citation)

The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.


4
Michael J Costanzo, Bruce E Maryanoff: Anticonvulsant fructopyranose cyclic sulfites and sulfates. McNeilab, Ralph R Palo, September 7, 1993: US05242942 (42 worldwide citation)

Compounds of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n and p are as herein defined; exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Compounds of this class are also useful for the treatment o ...


5
Michael J Costanzo, Bruce E Maryanoff: Peptidyl heterocycles useful in the treatment of thrombin related disorders. Ralph R Palo, June 4, 1996: US05523308 (42 worldwide citation)

Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.


6
Bruce E Maryanoff, Samuel O Nortey: Anticonvulsant phenethyl sulfamates. McNeilab, David J Levy, December 20, 1988: US04792569 (29 worldwide citation)

Sulfamates of the following formula (I) are anticonvulsants and are useful in the treatment of epilepsy: ##STR1## wherein R is one or more substituents such as alkyl, halo, alkoxy, CH.sub.3 or nitro; and


7
Michael J Costenzo, Bruce E Maryanoff, David F McComsey, Samuel O Nortey: Anticonvulsant pseudofructopyranose sulfamates. Ortho Pharmaceutical Corporation, Ralph R Palo, March 12, 1996: US05498629 (19 worldwide citation)

A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.


8
Bruce E Maryanoff: Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates. McNeil PPC, Ralph R Palo, November 2, 1993: US05258402 (19 worldwide citation)

Imidate derivatives of sulfamates having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as herein defined have been found to be useful prodrug and exhibit anticonvulsant activity when converted to the active agent upon administration to a mammal and are thus ...


9
Han Cheng Zhang, William J Hoekstra, Bruce E Maryanoff, David F McComsey: Indole peptidomimetics as thrombin receptor antagonists. Ortho McNeil Pharmaceutical, Millennium Pharmaceuticals, Gabrial Lopez, Hal B Woodrow, February 22, 2005: US06858577 (16 worldwide citation)

The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angi ...


10
Han Cheng Zhang, Bruce E Maryanoff, Anjali Pandey, Robert M Scarborough: Indazole peptidomimetics as thrombin receptor antagonists. Ortho McNeil Pharmaceutical, May 23, 2006: US07049297 (15 worldwide citation)

The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, An ...