1
Richard J Zelinka, Keiichi Itakura, Carl W Sims, Bruce E Kaplan: General purpose gene synthesizer. Systec, Orrin M Haugen, Thomas J Nikolai, July 1, 1986: US04598049 (94 worldwide citation)

A microprocessor controlled, general purpose gene synthesizer for programmably synthesizing selected nucleotide sequences. Depending upon a programmed chemistry, metered volumes of selected bases and reagent/solvents are sequentially metered into the bottom of a reaction cell containing solid-suppor ...


2
Steven S Smith, Bruce E Kaplan: RNA-DNA hybrid molecules of nucleic acid. City of Hope, Rothwell Figg Ernst & Kurz, January 13, 1998: US05708154 (40 worldwide citation)

Molecules having an RNA block linked to a shorter DNA block is described. The RNA and DNA blocks are complementary to accommodate formation of fold-back molecules having a 3' hydroxyl on the DNA block and an overhanging RNA strand at the end of a short DNA-RNA hybrid.


3
John J Rossi, Pairoj Chang, Bruce E Kaplan: Chimeric DNA-RNA catalytic sequences. City of Hope, Edward S Irons, September 22, 1992: US05149796 (39 worldwide citation)

This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences.


4
Timothy G Coakley, Alfred J Horton Jr, Bruce E Kaplan: Ozonation system for treatment of water in cooling towers. Reztek International, Schweitzer Cornman & Gross, August 17, 1993: US05236673 (13 worldwide citation)

An improved system for treatment of cooling tower water using ozone as a biocide. A self-contained unit is supplied with compressed air which is introduced to ozone generating electrodes at a constant flowrate. The ozone is mixed with tower water and then returned to the cooling tower. A sampling pr ...


5
Bruce E Kaplan, Piotr M Swiderski: Disposable reagent storage and delivery cartridge. City of Hope, Rothwell Figg Ernst & Kurz, June 16, 1998: US05766550 (11 worldwide citation)

A disposable cartridge for storage and delivery of reagents for synthesizing and labeling of synthetic oligonucleotides comprises an annular casing, an enclosed area defined by the interior surface of the casing and a non-swellable matrix which is inert to organic solvents is positioned within the e ...


6
Steven S Smith, Bruce E Kaplan: Mechanism based inhibitors of DNA methyltransferase. City of Hope, Edward S Irons, April 2, 1996: US05503975 (11 worldwide citation)

Novel synthetic oligomers of unique three-dimensional structure comprising homologous and heterologous blocks, some of which may self-associate are described. Also disclosed is a synthetic oligonucleotide that includes 5-fluorocytosine residues at positions corresponding to methylation sites of DNA- ...


7
Bruce E Kaplan: Portable clothes dryer and room humidifier. Sandra M Katin, March 7, 1995: US05394619 (10 worldwide citation)

A clothes dryer designed to rest over the register of a floor duct delivering hot air from a forced hot air heating system. The dryer is a vertical hollow column, closed at the top and open at the bottom, to which are attached one or more foldable drying racks on which the clothes are hung for dryin ...


8
Timothy G Coakley, Alfred J Horton Jr, Bruce E Kaplan: Ozone production electrode assembly. Rez Tek International, Schweitzer Cornman & Gross, July 26, 1994: US05332556 (9 worldwide citation)

An improved system for treatment of cooling tower water using ozone as a biocide. A self-contained unit is supplied with compressed air which is introduced to ozone generating electrodes at a constant flowrate. The ozone is mixed with tower water and then returned to the cooling tower. A sampling pr ...


9
Steven S Smith, Bruce E Kaplan: Reverse transcriptase detection and inhibition. City of Hope, Rothwell Figg Ernst & Kurz, April 4, 2000: US06045992 (1 worldwide citation)

A reverse transcriptase assay is described. A modular nanostructure comprising relatively small and relatively long RNA sequences is utilized in the assay.



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