1
Bruce D Roth: [R-(R*R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-( 1-methylethyl-3-phenyl-4-[(phenylamino) carbonyl]- 1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof. Warner Lambert Company, Ronald A Daignault, December 28, 1993: US05273995 (309 worldwide citation)

[R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-((1-methylethyl)- 3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid or (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl-N,4-diphenyl-1-[2-(tetrahyd ro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide; and pharmaceutic ...


2
Bruce D Roth: Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Jerry F Janssen, July 21, 1987: US04681893 (251 worldwide citation)

Certain trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase and are thus useful hypolipidemic or hyp ...


3
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, June 28, 1994: US05324483 (194 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


4
Milton L Hoefle, Bruce D Roth, Charlotte D Stratton: Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Jerry F Janssen, March 3, 1987: US04647576 (127 worldwide citation)

6-[2-(Substituted-pyrrol-1-yl)alkyl]pyran-2-ones and the corresponding ring-opened hydroxy-acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG-CoA reductase), and are thus useful hypolipidemic and hypocholesterolemic agents. Pharmaceutical ...


5
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, March 26, 1991: US05003080 (104 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...


6
Susan M Bjorge, Ann E Black, Bruce D Roth, Thomas Woolf: [(Hydroxyphenylamino) carbonyl] pyrroles. Warner Lambert Company, Charles W Ashbrook, January 31, 1995: US05385929 (85 worldwide citation)

2-(4-Fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[( hydroxyphenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, and their lactone forms, and salts and solyates thereof, inhibit cholesterol biosynthesis, and thus are useful in treating hypercholesterolemia.


7
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, March 17, 1992: US05097045 (76 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...


8
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, June 23, 1992: US05124482 (73 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans(.+-.)-5-(4 ...


9
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Company, Francis J Tinney, September 22, 1992: US05149837 (66 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-( ...


10
Donald E Butler, Carl F Deering, Alan Millar, Thomas N Nanninga, Bruce D Roth: Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis. Warner Lambert Co, Francis J Tinney, June 1, 1993: US05216174 (64 worldwide citation)

An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4 ...