1
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas D P Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt activity. Merck Sharp & Dohme, Matthew A Leff, David A Muthard, March 22, 2011: US07910561 (1 worldwide citation)

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


2
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas DP Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt Activity. Merck And Co, November 20, 2008: US20080287457-A1

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


3
Sunny Abraham, Shripad S Bhagwat, Brian T Campbell, Qi Chao, Raffaella Faraoni, Mark W Holladay, Andiliy G Lai, Martin W Rowbottom, Eduardo Setti, Kelly G Sprankle: RAF kinase modulator compounds and methods of use thereof. Ambit Biosciences Corporation, Jones Day, December 31, 2013: US08618289 (3 worldwide citation)

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically ac ...


4
Jeannie Arruda, Celine Bonnefous, Brian T Campbell, Rowena V Cube, Benito Munoz, Brian Stearns, Jean Michel Vernier, Bowei Wang, Xiumin Zhao: Metabotropic glutamate receptor-5 modulators. Merck & Co, David L Rose, David A Rubin, August 8, 2006: US07087601 (2 worldwide citation)

Phenyl compounds substituted at the 1-position with a fused bicyclo moeity formed from a five-membered heterocycle fused to a six-membered carbocycle, to a six-membered aryl, or to a six-membered hetaryl, and further optionally substituted at the 3,4 positions, are mGluR5 modulators useful in the tr ...


5
Sunny Abraham, Shripad S Bhagwat, Brian T Campbell, Qi Chao, Raffaella Faraoni, Mark W Holladay, Andiliy G Lai, Martin W Rowbottom, Eduardo Setti, Kelly G Sprankle: RAF kinase modulator compounds and methods of use thereof. Ambit Biosciences Corporation, Jones Day, March 3, 2015: US08969587 (1 worldwide citation)

Compounds, compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases.


6
Sunny Abraham, Shripad S Bhagwat, Brian T Campbell, Qi Chao, Raffaella Faraoni, Mark W Holladay, Andiliy G Lai, Martin W Rowbottom, Eduardo Setti, Kelly G Sprankle: RAF kinase modulator compounds and methods of use thereof. Ambit Biosciences Corporation, Knobbe Martens Olson & Bear, April 26, 2016: US09320739

Compositions of 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1, -trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disor ...


7
Jeannie Arruda, Celine Bonnefous, Brian T Campbell, Rowena V Cube, Benito Munoz, Brian Stearns, Jean Michel Vernier, Bowei Wang, Xiumin Zhao: Metabotropic glutamate receptor-5 modulators. David L Rose, Merck & Co Patent Department, March 24, 2005: US20050065340-A1

Phenyl compounds substituted at the 1-position with a fused bicyclo moeity formed from a five-membered heterocycle fused to a six-membered carbocycle, to a six-membered aryl, or to a six-membered hetaryl, and further optionally substituted at 2 the 3,4 positions, are mGluR5 modulators useful in the ...


8
Sunny Abraham, Shripad S Bhagwat, Brian T Campbell, Qi Chao, Raffaella Faraoni, Mark W Holladay, Andiliy G Lai, Martin W Rowbottom, Eduardo Setti, Kelly G Sprankle: Raf kinase modulator compounds and methods of use thereof. May 19, 2011: US20110118245-A1

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically ac ...



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