1
Brian Froehler, Robert J Jones: Oligonucleotides containing 5-propynyl pyrimidines. Gilead Sciences, Daryl D Muenchau, January 16, 1996: US05484908 (341 worldwide citation)

Oligonucleotides with enhanced hybridization binding possessing 5-propynyluracil and/or 5-propynylcytosine in place of uracil and cytosine, respectively. These oligonucleotides are useful in traditional hybridization assays for detection of a specific DNA sequence.


2
Brian Froehler, Mark Matteucci: Enhanced triple-helix and double-helix formation with oligomers containing modified purines. Gilead Sciences, Daryl D Muenchau, January 14, 1997: US05594121 (296 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain 7-deaza-7-substituted purines or related analogs. The oligomers of the invention are capable of (i) forming triple ...


3
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, July 8, 1997: US05645985 (288 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


4
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Methods of using oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, November 3, 1998: US05830653 (280 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


5
Brian Froehler: Oligonucleotides with inverted polarity. Gilead Sciences, Morrison & Foerster, March 21, 1995: US05399676 (232 worldwide citation)

Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity,


6
Chris Buhr, Mark Matteucci, Norbert W Bischofberger, Brian Froehler: Nucleoside 5-methylene phosphonates. Gilead Sciences, Daryl D Muenchau, September 30, 1997: US05672697 (141 worldwide citation)

Novel oligonucleotides analogs and nucleoside analogs as well as methods for their synthesis are described. The oligonucleotides are useful in diagnostic and therapeutic applications. The oligonucleotides are stable to nuclease degradation.


7
Brian Froehler: Oligonucleotides with inverted polarity. Gilead Sciences, Mark L Bosse, June 18, 1996: US05527899 (127 worldwide citation)

Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleo ...


8
Brian Froehler: Oligonucleotides with inverted polarity. Gilead Sciences, Daryl D Muenchau, February 24, 1998: US05721218 (106 worldwide citation)

Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula:


9
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines. ISIS Pharmaceuticals, ISIS Patent Department, Woodcock Washburn, April 5, 2005: US06875593 (61 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


10
Brian Froehler, Rick Wagner, Mark Mattencci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines. ISIS Pharmaceuticals, Woodcock Wahsburn Kurtz Mackiewicz & Norris, April 30, 2002: US06380368 (18 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...



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