1
Brian C Froehler: Exonuclease-resistant oligonucleotides. Gilead Sciences, Morrison & Foerster, October 26, 1993: US05256775 (264 worldwide citation)

A method is provided for making 3' and/or 5' end-capped oligonucleotides so as to render the oligonucleotide resistant to degradation by exonucleases. The exonuclease degradation resistance is provided by incorporating two or more phosphoramidate and phosphorocmonothioate and/or phosphorodithioate l ...


2
Brian C Froehler, Chris A Buhr: Hydrogen phosphonodithioate compositions. Gilead Sciences, Morrison & Foerster, March 16, 1993: US05194599 (112 worldwide citation)

Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be thera ...


3
Brian C Froehler, Chris A Buhr: Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues. Gilead Sciences, Mark L Bosse, October 15, 1996: US05565555 (106 worldwide citation)

Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be thera ...


4
Brian C Froehler, Mark D Matteucci: Intermediates. Genentech, September 25, 1990: US04959463 (60 worldwide citation)

A method is provided for the high fidelity, rapid and economical in vitro synthesis of oligonucleotides. Nucleoside H-phosphonates are condensed in seriatim using a dehydrating agent to produce a poly (nucleoside H-phosphonate). The produce is oxidized to yield the desired oligonucleotide. A novel r ...


5
Brian C Froehler, Mark D Matteucci: Method for in vitro oligonucleotide synthesis using H-phosphonates. Genentech, November 23, 1993: US05264566 (56 worldwide citation)

A method is provided for the high fidelity, rapid and economical in vitro synthesis of oligonucleotides. Nucleoside H-phosphonates are condensed in seriatim using a dehydrating agent to produce a poly (nucleoside H-phosphonate). The product is oxidized to yield the desired oligonucleotide. A novel r ...


6
Brian C Froehler, Kenneth M Kent, Sylvia Wu: Monomethoxytrityl protected oligonucleotides bound to a solid support. April 20, 1993: US05204455 (10 worldwide citation)

The present invention describes methods for the production of oligonucleotides under conditions which exploit the desirable characteristics, such as the property of sustaining high degrees of substitution, of functionalized organic polymeric supports while avoiding the sluggish kinetics and low rate ...


7
Brian C Froehler, Arnold J Gutierrez, Mark D Matteucci: 2-Aminopyridine and 2-pyridone C-nucleosides, oligonucleotides comprising, and tests using the same oligonucleotides. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, September 10, 2002: US06447998 (10 worldwide citation)

The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation throug ...


8
Brian C Froehler, Arnold J Gutierrez, Mark D Matteucci: Oligonucleotides including 2-aminopyridine and 2-pyridone C-nucleoside units. ISIS Pharmaceuticals, Woodcock Washburn, December 17, 2002: US06495672 (10 worldwide citation)

The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation throug ...


9
Brian C Froehler, Kenneth M Kent, Sylvia Wu: Large scale synthesis of oligonucleotides and their associated analogs. Gilead Sciences, November 17, 1992: US05164491 (9 worldwide citation)

The present invention describes methods for the production of oligonucleotides under conditions which exploit the desirable characteristics, such as the property of sustaining high degrees of substitution, of functionalized organic polymeric supports while avoiding the sluggish kinetics and low rate ...


10
Brian C Froehler, Mark D Matteucci: Method of making oligonucleotides, oligonucleoside thiophosphates and oligonucleoside phosphotriesters using H-phosphonate intermediates. Genentech, August 20, 1996: US05548076 (7 worldwide citation)

A method is provided for the high fidelity, rapid and economical in vitro synthesis of oligonucleotides. Nucleoside H-phosphonates are condensed in seriatim using a dehydrating agent to produce a poly (nucleoside H-phosphonate). The product is oxidized to yield the desired oligonucleotide. A novel r ...



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