1
Burnett Duane A, Clader John W, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Mcallister Timothy, Colon Cesar, Barton Derek H R, Breslow Ronald, Dugar Sundeep, Vaccaro Wayne: Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof.. Schering, January 27, 1993: EP0524595-A1 (40 worldwide citation)

Novel compounds of the formula wherein A is -CH=CH-B; -C IDENTICAL C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or-S(O)0-2; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or wherein k is 1-2; D is B'-(CH2)mC(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2-6; B'-(C ...


2
Breslow Ronald, Miller Thomas A, Belvedere Sandro, Marks Paul A, Richon Victoria M, Rifkind Richard A: Hydroxamic acid compounds and methods of use thereof. Memorial Sloan Kettering Cancer Center, The Trustees Of Columbia University In The City Of New York, Breslow Ronald, Miller Thomas A, Belvedere Sandro, Marks Paul A, Richon Victoria M, Rifkind Richard A, ELRIFI Ivor R, October 21, 2004: WO/2004/089293 (12 worldwide citation)

The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to ...


3
BRESLOW Ronald, MARKS Paul A: [fr] NOUVELLES MOLÉCULES QUI INHIBENT SÉLECTIVEMENT LHISTONE-DÉACÉTYLASE 6 PAR RAPPORT À LHISTONE-DÉACÉTYLASE 1, [en] NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1. BRESLOW Ronald, MARKS Paul A, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH, WHITE John P, April 11, 2013: WO/2013/052110 (5 worldwide citation)

[en] The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from protein ...


4
Breslow Ronald, Marks Paul A, Rifkind Richard A, Jursic Branko: New effective terminal differentiation-inducing agent and its use. Sloan Kettering Inst For Cancer Research, Trustees Of Columbia Univ In The City Of New York, August 12, 2003: JP2003-226680 (4 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for selectively inducing the terminal differentiation of tumor cells and thereby inhibiting the propagation of the cells, and a method for treating a patient having the tumor cells in the propagation.SOLUTION: This compound is expressed by formula (1) [where ...


5

6
Marks Paul A, Rifkind Richard A, Breslow Ronald, Jursic Branko: Novel potent inducers of terminal differentiation and method of use thereof. Sloan Kettering Inst Cancer, Univ Columbia, May 4, 1994: EP0594577-A1 (3 worldwide citation)

The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and ...


7
Burnett Duane A, Clader John W, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Mcallister Timothy, Colon Cesar, Barton Derek H R, Breslow Ronald, Dugar Sundeep, Vaccaro Wayne: Composes beta-lactame substitues utilises comme agents hypocholesterolemiants et procedes pour leur preparation, Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof. Schering Corporation, Schering Corporation, OGILVY RENAULT SENCRLSRL, February 4, 1993: CA2114007 (1 worldwide citation)

Novel compounds of formula (I) wherein A is -CH = CH-B; -C .ident. C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or -S(O)0-2-; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or (Ia), wherein k is 1-2; D is B'-(CH2)m C(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2 ...


8
Breslow Ronald, Baldwin Steven, Winnik Michell: Remote oxidation of unactivated steroid methylene groups. August 15, 1972: US3684801 (1 worldwide citation)

There is provided a method of activating inactive methylene groups of the 5.alpha.-steroid nucleus. This method comprises forming a 3.alpha.-m- or p-benzoylphenyl 5.alpha.-steroid alkanoate and irradiating said ester in ultraviolet light in the presence of a solvent. Upon saponification of the ester ...


9
Marks Paul A, Rifkind Richard A, Breslow Ronald, Jursic Branko: Novel potent inducers of terminal differentiation and method of use thereof. Sloan Kettering Institute For Cancer Research, The Trustees Of Columbia University In The City Of New York, Marks Paul A, Rifkind Richard A, Breslow Ronald, Jursic Branko, WHITE John P, June 13, 1991: WO/1991/008191 (1 worldwide citation)

The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and ...


10
Richon Victoria M, Marks Paul A, Rifkind Richard A, Breslow Ronald, Belvedere Sandro, Gershell Leland, Miller Thomas A: Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof. Sloan Kettering Inst Cancer, Univ Columbia, August 21, 2002: EP1231919-A2

The present invention provides the compound having formula (I), wherein each of R>122<-; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting p ...