1
Schmidt Gunter Dr, Brandes Arndt Dr, Angerbauer Rolf Dr, Loegers Michael Dr, Mueller Gliemann Matthias Dr, Schmeck Carsten Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr, Giera Henry Dr, Paulsen Holger Dr, Naab Paul Dr, Conrad Michael Dr, Stoltefuss Juergen: Cycloalkano-pyridine as cetp inhibitors. Bayer, January 14, 1998: EP0818448-A1 (95 worldwide citation)

Cycloalkano-pyridine compounds of formula (I) and their salts and N-oxides are new. A = 6-10C aryl (optionally up to penta-substituted by halo, NO2, OH, CF3, OCF3, 1-7C alkyl, 1-7C acyl, 1-7C hydroxyalkyl, 1-7C alkoxy or NR3R4); R3, R4 = H, phenyl or 1-6C alkyl; D = 6-10C aryl (optionally substitute ...


2
Schmeck Carsten Dr, Mueller Gliemann Matthias Dr, Schmidt Gunther Dr, Brandes Arndt Dr, Angerbauer Rolf Dr, Loegers Michael Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr: Heterocyclic condensed pyridines as cetp inhibitors. Bayer, January 14, 1998: EP0818197-A1 (86 worldwide citation)

Condensed pyridine derivatives of formula (I), and their salts and N-oxides, are new. A = 6-10C aryl (optionally mono- to penta-substituted by halo, OH, CF3, OCF3, NO2, 1-7C alkyl, acyl, hydroxyalkyl or alkoxy, or NR3R4; D = XR5or C(R6)(R7)R8; R5, R6 = 3-8C cycloalkyl, 6-10C aryl, or 5-7 membered he ...


3
Schmidt Gunter Dr, Angerbauer Rolf Dr, Brandes Arndt Dr, Loegers Michael Dr, Mueller Gliemann Matthias Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Wohlfeil Stefan Dr: 2-aryl substituted pyridines. Bayer, September 24, 1997: EP0796846-A1 (41 worldwide citation)

2,6-Diaryl-3-alkyl-4-(alkyl or alkenyl)-5-(alkyl or cycloalkyl)-pyridine derivatives of formula (I) and their salts are new. A, E = 6-10C aryl (optionally mono- to penta- substituted by halo, OH, CF3, OCF3, NO2, -NRR, 1-7C alkyl, 1-7C acyl, 1-7C hydroxyalkyl or 1-7C alkoxy); D = 1-8C hydroxyalkyl; L ...


4
Brandes Arndt Dr, Loegers Michael Dr, Schmidt Gunter Dr, Angerbauer Rolf Dr, Schmeck Carsten Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr: Pyridine fused to a bicyclic ring. Bayer, February 25, 1998: EP0825185-A1 (5 worldwide citation)

Bicyclic condensed pyridine compounds of formula (I) and their salts and N-oxides are new. A = 6-10C aryl optionally substituted by 1-3 halo, OH, CF3, OCF3 or 1-7C alkyl, acyl, hydroxyalkyl or alkoxy groups, or by one NR3R4 group; R3, R4 = independently H, phenyl or 1-6C alkyl; D = R5-T- or (R6)(R7) ...


5
Brandes Arndt Dr, Loegers Michael Dr, Schmidt Gunter Dr, Rorufu Angaabauaa, Schmeck Carsten Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr: Bicyclic-condensed pyridine. Bayer, March 10, 1998: JP1998-067751

PROBLEM TO BE SOLVED: To obtain a new compound, having inhibiting activities against a cholesterol ester transfer protein and useful for treating hyperproteinemia, atherosclerosis, etc. SOLUTION: This compound is represented by formula I [A is a substitutable 6-10C aryl; D is R5-T or formula II (R5 ...


6
Schmidt Gunter Dr, Brandes Arndt Dr, Rorufu Angaabauaa, Loegers Michael Dr, Mueller Gliemann Matthias Dr, Schmeck Carsten Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr, Henry Giera, Holger Paulsen, Naab Paul, Michael Conrad, Juergen Stoltefus: Cycloalkanolpyridine. Bayer, March 10, 1998: JP1998-067746

PROBLEM TO BE SOLVED: To obtain a novel compound which is useful for the treatment of atherosclerosis and hyperlipoproteinemia. SOLUTION: This novel compound is represented by formula I[A is a (substituted) 6-10C aryl; D is a (substituted)6-10C aryl, the formula: R5L-(R5 is a 3-6C cycloalkyl; L is a ...


7
Schmeck Carsten Dr, Mueller Gliemann Matthias Dr, Schmidt Gunter Dr, Brandes Arndt Dr, Rorufu Angaabauaa, Loegers Michael Dr, Bremm Klaus Dieter Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Schuhmacher Joachim Dr: Heterocyclic-condensed pyridines. Bayer, June 23, 1998: JP1998-167967

PROBLEM TO BE SOLVED: To obtain the subject compound useful for treatment and prevention of heterolipidemia or atherosclerosis. SOLUTION: This compound is expressed by formula I [A is an 6-10C aryl; D is formula II or III (R5 and R6 are each a 3-8C cycloalkyl; X is an alkylene of 8C or less and the ...


8
Schmidt Gunter Dr, Rorufu Angaabauaa, Brandes Arndt Dr, Loegers Michael Dr, Mueller Gliemann Matthias Dr, Bischoff Hilmar Dr, Schmidt Delf Dr, Wohlfeil Stefan Dr: 2-aryl-substituted pyridine compounds. Bayer, September 30, 1997: JP1997-255574

PROBLEM TO BE SOLVED: To obtain a pyridine compound capable of lowering the level of LDL cholesterol and simultaneously raising the level of HDL cholesterol in blood and mainly useful for treating hyperlipoproteinemia, hypolipoproteinemia and arteriosclerosis. SOLUTION: A 2-aryl-substituted pyridine ...