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Santus Giancarlo, Bottoni Giuseppe, Bilato Ettore: Liquid-suspension controlled-release pharmaceutical composition.. Recordati Chem Pharm, June 15, 1994: EP0601508-A2 (14 worldwide citation)

Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coatings of polymeric hydrophilic and hydrophobic materials, the first applied of said coat ...


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Santus Giancarlo, Bottoni Giuseppe, Sala Giovanni: Pharmaceutical controlled-release composition with bioadhesive properties.. Recordati Chem Pharm, December 2, 1992: EP0516141-A1 (13 worldwide citation)

A pharmaceutical composition for the controlled release of medicinal drugs, which has the property of adhering to biologic tissues is described. The characteristic features of the composition are a plurality of small-size units capable of ensuring a gradual release of the active ingredient they cont ...


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Santus Giancarlo, Bottoni Giuseppe, Bilato Ettore: Therapeutic compositions for intranasal administration which include ketorolac tm.. Recordati Chem Pharm, January 27, 1993: EP0524587-A1 (9 worldwide citation)

New therapeutic compositions with analgesic and anti-inflammatory activity, for intranasal administration comprising as active ingredient an effective amount, comprised from 0.5 and 40 mg per dose, of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (Ketorolac TM ) in racemic or optically acti ...


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Santus Giancarlo, Bottoni Giuseppe, Golzi Roberto: Process for the preparation of microgranules suitable for suspension after coating in pharmaceutical liquid compositions.. Recordati Chem Pharm, August 3, 1994: EP0608850-A1 (7 worldwide citation)

Object of the invention is a process for the preparation of microgranules to be used after coating in liquid pharmaceutical compositions, particularly in controlled-release compositions. Operating with high-shear mixer-granulators within clearly established crucial parameter ranges, this process per ...


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Maffei Paola, Bachetti Milena, Bottoni Giuseppe, Viscomi Giuseppe Claudio: Use of polyols to obtain stable polymorphous forms of rifaximin. Alfa Wassermann, Maffei Paola, Bachetti Milena, Bottoni Giuseppe, Viscomi Giuseppe Claudio, March 13, 2008: WO/2008/029208 (2 worldwide citation)

Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations ...


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Gatti Gaetano, Oldani Diego, Bottoni Giuseppe, Confalonieri Carlo, Gambini Luciano, Ponti Roberto de: Injectable ready-to-use solutions containing an antitumor anthracycline glycoside. Erba Carlo, July 27, 1988: GB2200047-A (1 worldwide citation)

A storage stable, sterile, pyrogen-free, injectable anthracycline glycoside solution consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and the pH of ...


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Gatti Gaetano, Oldani Diego, Bottoni Giuseppe, Confalonieri Carlo, Gambini Luciano, de Ponti Roberto: Injectable ready-to-use solutions containing an antitumor anthracycline glycoside.. Erba Carlo, July 24, 1991: EP0438183-A1 (1 worldwide citation)

A storage stable, sterile, pyrogen-free, injectable anthracycline glycoside solution consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and the pH of ...


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Bottoni Giuseppe, Maffei Paola, Sforzini Annalisa, Federici Mascia, Caramella Carla, Rossi Silvia, Viscomi Giuseppe Claudio: Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical presentations. Alfa Wassermann, March 19, 2008: EP1898876-A1 (1 worldwide citation)

Object of the invention are mucoadhesive and controlled release formulations consisting of aqueous solutions containing 0.05% to 5% by weight of a natural purified polymer having xyloglucan structure and 10% to 70% by weight of glycerol. These formulations are suitable for the application on human m ...


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Bottoni Giuseppe, Maffei Paola, Sforzini Annalisa, Federici Mascia, Caramella Carla, Rossi Silvia, Viscomi Giuseppe Claudio: Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations. Alfa Wassermann, Bottoni Giuseppe, Maffei Paola, Sforzini Annalisa, Federici Mascia, Caramella Carla, Rossi Silvia, Viscomi Giuseppe Claudio, BIANCHETTI Giuseppe, December 14, 2006: WO/2006/131262 (1 worldwide citation)

Object of the invention are mucoadhesive and controlled release formulations consisting of aqueous solutions containing 0.05% to 5% by weight of a natural purified polymer having xyloglucan structure and 10% to 70% by weight of glycerol. These formulations are suitable for the application on human m ...