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Severance Daniel L, Gardiner Elisabeth Mm, Noble Stewart A, Lou Boliang, Borchardt Allen J, Kahraman Mehmet, Roppe Jeffrey R, Siegel Dana L, Scranton Shawn A: Ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders. Kalypsys, Severance Daniel L, Gardiner Elisabeth Mm, Noble Stewart A, Lou Boliang, Borchardt Allen J, Kahraman Mehmet, Roppe Jeffrey R, Siegel Dana L, Scranton Shawn A, HO Raymond J, November 2, 2006: WO/2006/116355 (12 worldwide citation)

The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neur ...


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Severance Daniel L, Borchardt Allen J, Gardiner Elisabeth M M, Kahraman Mehmet: Inhibitors of p38 kinase and methods of treating inflammatory disorders. Kalypsys, Severance Daniel L, Borchardt Allen J, Gardiner Elisabeth M M, Kahraman Mehmet, HO Raymond J, February 8, 2007: WO/2007/015866 (9 worldwide citation)

The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neur ...


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Borchardt Allen J, Siegel Dana L, Gardiner Elisabeth M M, Scranton Shawn A, Severance Daniel L, Noble Stewart A, Lou Boliang: Inhibitors of p38 kinase and methods of treating inflammatory disorders. Kalypsys, Borchardt Allen J, Siegel Dana L, Gardiner Elisabeth M M, Scranton Shawn A, Severance Daniel L, Noble Stewart A, Lou Boliang, HO Raymond J, February 8, 2007: WO/2007/015877 (8 worldwide citation)

The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neur ...


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Chu Shao Song, Alegria Larry Andrew, Bender Steven Lee, Benedict Suzanne Pritchett, Borchardt Allen J, Kania Robert Steven, Nambu Mitchell David, Tempczyk Russell Anna Maria, Sarshar Sepehr, Bhumralkar Dilip, Peng Zhengwei, Yang Yi Michelle: Diaminothiazoles and their use for inhibiting protein kinases. Agouron Pharmaceuticals, PINO Mark J, December 14, 2000: WO/2000/075120 (4 worldwide citation)

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell ...


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BORCHARDT ALLEN J: Heterocyclic inhibitors of histamine receptors for the treatment of disease. KALYPSYS, Bennett Dennis A, March 18, 2010: WO/2010/030785 (3 worldwide citation)

The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.


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Kania Robert Steven, Bender Steven Lee, Borchardt Allen J, Braganza John F, Cripps Stephan James, Hua Ye, Johnson Michael David, Johnson Theodore Otto Jr, Luu Hiep The, Palmer Cynthia Louise, Reich Siegfried Heinz, Tempczyk Russell Anna Maria, Teng Min, Thomas Christine, Varney Michael David, Wallace Michael Brennan, Collins Michael Raymond: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, PINO Mark J, January 11, 2001: WO/2001/002369 (3 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...