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Bernard R Belleau, Terrence W Doyle, Bing Yu Luh, Terry T Conway: .DELTA..sup.2,3 -1,4-MORPHOLINE-2-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF USEFUL IN PREPARATION OF ANTIBACTERIA AGENTS. Bristol Myers Company, David M Morse, March 15, 1977: US04012383 (6 worldwide citation)

There is described novel substituted .DELTA..sup.2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen o ...


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Bernard R Belleau, Terrence W Doyle, Bing Yu Luh, Terry T Conway: O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents. Bristol Myers Company, David M Morse, December 27, 1977: US04065623 (2 worldwide citation)

There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring sys ...


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Bernard R Belleau, Terrence W Doyle, Bing Yu Luh, Terry T Conway: O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents. Bristol Myers Company, David M Morse, January 3, 1978: US04066831 (1 worldwide citation)

There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused .alpha.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring sy ...


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Bernard R Belleau, Terrence W Doyle, Bing Yu Luh, Terry T Conway: .DELTA..sup.2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents. Bristol Myers Company, David M Morse, September 12, 1978: US04113946 (1 worldwide citation)

There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring syst ...


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Bernard R Belleau, Terrence W Doyle, Bing Yu Luh, Terry T Conway: O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents. Bristol Myers Company, David M Morse, October 23, 1979: US04172199

There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring syst ...


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Joanne J Bronson, Stanley V D Andrea, Shelley E Hoeft, John D Matiskella, Peter F Misco Jr, Bing Yu Luh, Dane M Springer, Yasutsugu Ueda, John A Wichtowski: Substituted 4-thio pyridones. Bristol Myers Squibb Company, David M Morse, September 16, 1997: US05668290

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R.sup.1 represents either the residue of a heterocyclic amino acid or a C.sub.2 - ...