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Bigge Christopher Franklin, Hays Sheryl Jeanne, Johnson Graham, Novak Perry Michael, Ortwine Daniel Fred: Polycyclic amines useful as cerebrovascular agents.. Warner Lambert Co, September 26, 1990: EP0388977-A2 (5 worldwide citation)

A novel series of polycyclic amine derivatives, of formula I methods of making the compounds, novel intermediates, compositions containing them, and pharmaceutical compositions useful in the treatment and prevention of cerebrovascular disorders and useful as anesthetics or analgesics.


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Bigge Christopher Franklin, Drummond James Thomas, Gregor Vlad Edward, Johnson Graham, Pavia Michael Raymond: Substituted alpha-amino acids having pharmaceutical activity.. Warner Lambert Co, June 7, 1989: EP0318935-A2 (5 worldwide citation)

The present invention is novel substituted a-amino acids, pharmaceutical compositions, methods of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.


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Bigge Christopher Franklin, Casimiro Garcia Agustin, Lee Chitase, Risley Hud Lawrence, Schaum Robert Philip: Compounds having both angiotensin ii receptor antagonism and ppary activating activities. Pfizer Products, Bigge Christopher Franklin, Casimiro Garcia Agustin, Lee Chitase, Risley Hud Lawrence, Schaum Robert Philip, FULLER Grover F, July 17, 2008: WO/2008/084303 (4 worldwide citation)

Compounds of following formula (I) are provided that have both angiontensin Il receptor antagonist activity and PPARy agonist activity. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment of diseases with the compounds including type 2 diabetes, insulin re ...


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Bigge Christopher Franklin, Dudley Danette Andrea, Edmunds Jeremy John, Van, Huis Chad Alan, Casimiro Garcia Agustin, Filipski Kevin James, Kohrt Jeffrey Thomas: Inhibitors of factor xa and other serine proteases involved in the coagulation cascade. Warner Lambert Company, Bigge Christopher Franklin, Dudley Danette Andrea, Edmunds Jeremy John, Van, Huis Chad Alan, Casimiro Garcia Agustin, Filipski Kevin James, Kohrt Jeffrey Thomas, LUMB J Trevor, June 5, 2003: WO/2003/045912 (2 worldwide citation)

The present invention provides compounds of Formula (I), wherein A, B, C, G, and W?1¿ have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or mor ...


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Guo Chuangxing, Augelli Szafran Corinne E, Barta Nancy Sue, Bender Steven Lee, Bigge Christopher Franklin, Caprathe Bradley William, Chatterjee Arindam, Deal Judith, Dong Liming, Fay Lorraine Kathleen, Hou Xinjun, Hudack Raymond Andrew Jr: Heterobicycles fkbp-ligands. Agouron Pharma, June 2, 2004: EP1423119-A1

Diazabicyclo[3.3.1]nonane derivatives that inhibit the peptidyl-prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described for treating neurological disorders. Also described are compounds useful for preparing such inhibitors.


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Bigge Christopher Franklin, Johnson Graham, Taylor Charles Price Jr, Welty Devin Franklin: Preparation pharmaceutique contenant un agent uricosurique et un antagoniste des acides amines excitateurs, Pharmaceutical preparation containing an uricosuric agent and an excitatory amino acid antagonist. Warner Lambert Company, Warner Lambert Company, MACRAE & CO, March 18, 1993: CA2115442

The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excit- atory amino acid antagonist.


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Bigge Christopher Franklin, Dudley Danette Andrea, Edmunds Jeremy John, Van Huis Chad Alan, Casimiro Garcia Agustin, Filipski Kevin James, Kohrt Jeffrey Thomas: Inhibiteurs du facteur xa et autres serine proteases intervenant dans la cascade de la coagulation, Inhibitors of factor xa and other serine proteases involved in the coagulation cascade. Warner Lambert Company, Warner Lambert Company, Torys, March 29, 2011: CA2468715

The present invention provides compounds of Formula (I), wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more ...


10
Barta Nancy Sue, Bigge Christopher Franklin: Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoidane derivatives. Warner Lambert Co, February 26, 2003: EP1284958-A1

The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R and R include alkyl and phenylalkyl; R is hydrogen or alkyl; and R4 and R5 include alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a m ...