1
John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds, December 7, 1993: US05268164 (95 worldwide citation)

Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more ...


2
Bernard Malfroy Camine: Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability. Alkermes, Hamilton Brook Smith & Reynolds, May 12, 1992: US05112596 (76 worldwide citation)

The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe.sup.8 (CH.sub.2 -NH)Arg.sup.9 ] bradykinin, to ...


3
John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds, April 9, 1996: US05506206 (67 worldwide citation)

Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more ...


4
John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds P C, November 11, 1997: US05686416 (56 worldwide citation)

Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose des ...


5
Bernard Malfroy Camine, Michel Baudry: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Tracy J Dunn, April 4, 1995: US05403834 (40 worldwide citation)

The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.


6
Bernard Malfroy Camine, Susan Robin Doctrow: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Townsend and Townsend and Crew, December 9, 1997: US05696109 (35 worldwide citation)

The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat a disease as ...


7
Bernard Malfroy Camine, Susan Doctrow: Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases. Eukarion, Townsend & Townsend & Crew, July 8, 2003: US06589948 (21 worldwide citation)

This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease ...


8
Bernard Malfroy Camine, Susan Robin Doctrow: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Townsend and Townsend and Crew, November 10, 1998: US05834509 (20 worldwide citation)

This invention provides salen-manganese complexes and pharmaceutically acceptable compositions thereof useful as antioxidants and free radical scavengers.


9
Bernard Malfroy Camine, Susan Robin Doctrow: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Townsend & Townsend & Crew, April 4, 2000: US06046188 (17 worldwide citation)

The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a ...


10
Bernard Malfroy Camine, Susan Robin Doctrow: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Townsend and Townsend and Crew, October 27, 1998: US05827880 (13 worldwide citation)

The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a ...