1
Bernard Hulin, Janice C Parker: Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, March 23, 2004: US06710040 (53 worldwide citation)

The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, suc ...


2
Bernard Hulin: 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, April 26, 1994: US05306726 (42 worldwide citation)

Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.


3
Bernard Hulin, Reinhard Sarges: Glycogen phosphorylase inhibitors. Pfizer, Peter C Richardson, Gregg C Benson, Martha A Gammill, December 7, 1999: US05998463 (36 worldwide citation)

This invention relates to certain 5-acyl-2-oxo-indole-3-carboxamides useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds. This invention also relates ...


4
Bernard Hulin: 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents. Pfizer, Peter C Richardson, J Trevor Lumb, D Stuart McFarlin, February 18, 1992: US05089514 (33 worldwide citation)

Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl, or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.


5
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, Gregg C Benson, Mervin E Brokke, June 29, 1993: US05223522 (31 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond;


6
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, J Trevor Lumb, Mervin E Brokke, June 9, 1992: US05120754 (27 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and dB are each independently CH or N, with the proviso that when A or B is N, the other is CH;


7
David A Clark, Steven W Goldstein, Bernard Hulin: Hypoglycemic thiazolidinedione derivatives. Pfizer, J Trevor Lumb, Robert K Blackwood, Richardson Peter C, July 30, 1991: US05036079 (26 worldwide citation)

Hypoglycemic thiazolidine-2,4-derivatives ##STR1## wherein the dotted line represents a bond or no bond; V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S;


8
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, J Trevor Lumb, Mervin E Brokke, October 29, 1991: US05061717 (26 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH;


9
Bernard Hulin: 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, August 3, 1993: US05232945 (26 worldwide citation)

A method of using certain 3-aryl-2-hydroxypropionic acid derivatives and analogs in the treatment of hypertension.


10
Robert L Dow, Bernard Hulin, David A Clark: Oxazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, March 12, 1996: US05498621 (21 worldwide citation)

Compounds of the formulae ##STR1## where R is cycloalkyl or aryl; R.sub.1 is alkyl, X is O or C.dbd.O; A is O or S; and B is N or CH are useful as hypoglycemic agents.