1
Berg Richard A, Rhee Woonza M: Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery.. Collagen, March 1, 1995: EP0640647-A2 (48 worldwide citation)

The present invention pertains to the use of glycosaminoglycans, chemically derivatized glycosaminoglycans, and optionally, chemically derivatized collagens to form ionically crosslinked gels useful in mammal soft tissue augmentation and in drug delivery systems. The derivatized glycosaminoglycans c ...


2
Rhee Woonza M, Berg Richard A: Collagen-synthetic polymer matrices prepared using a multiple step reaction.. Collagen, November 8, 1995: EP0680990-A1 (32 worldwide citation)

The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer matrix. The synt ...


3
Rhee Woonza M, Berg Richard A: Glycosaminoglycan-synthetic polymer conjugates.. Collagen, June 7, 1995: EP0656215-A1 (30 worldwide citation)

Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chon ...


4
Rosenblatt Joel S, Berg Richard A: Collagen-based injectable drug delivery system and its use.. Collagen, September 13, 1995: EP0671165-A2 (26 worldwide citation)

Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composi ...


5
Berg Richard A, Rhee Woonza Min: Composition for revitalizing scar tissue.. Collagen, February 8, 1995: EP0637450-A2 (23 worldwide citation)

In accordance with the present invention, a method is disclosed for the remediation of scar tissue in a human or an animal by introducing into the scar tissue or into tissue adjacent the scar tissue a remedial composition comprising a bioactive material selected from naturally occurring growth facto ...


6
Rhee Woonza M, Delustro Frank A, Berg Richard A: Crosslinked polymer compositions and methods for their use. Collagen, November 11, 1998: EP0876165-A1 (19 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


7
Berg Richard A, Rosenblatt Joel S, Rhee Woonza M: In situ crosslinkable, injectable collagen composition for tissue augmention. Collagen, May 29, 1996: EP0713707-A1 (16 worldwide citation)

The present invention discloses a novel, injectable crosslinked collagen composition which is able to continue crosslinking after injection to a soft or hard tissue site in order to anchor the collagen implant to the host tissue. The composition comprises particulate crosslinked collagen, noncrossli ...


8
Silver Frederick H, Berg Richard A, Doillon Charles J, Chernomorsky Arkady, Olson Robert M: Biodegradable collagen compositions for treatment of skin wounds.. Univ New Jersey Med, May 3, 1989: EP0314109-A2 (12 worldwide citation)

There is described a biodegradable collagen flake product and a biodegradable collagen sponge or sponge-like material. The collagen flake product is characterized by collagen fibers of non-uniform size, length and thickness, which fibers form flakes which define non-uniform channels connecting the s ...


9
Rhee Woonza M, Berg Richard A, Chu George H, Delustro Frank A, Jolivette Dan M, Mccullough Kimberly A: Use of injectable or implantable biomaterials for filling or blocking lumens and voids of the body. Collagen, November 11, 1998: EP0876166-A1 (11 worldwide citation)

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistul ...


10
Berg Richard A, Toman Paul David, Wallace Donald G: Mutated recombinant collagens. Collagen, March 6, 1996: EP0699752-A2 (8 worldwide citation)

The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent recognition site ...