1
Esau Christine, Lollo Bridget, Bennett C Frank, Freier Susan M, Griffey Richard H, Baker Brenda F, Vickers Timothy, Marcusson Eric G, Koller Erich, Swayze Eric E, Jain Ravi, Bhat Balkrishen, Peralta Eigen: Oligomeric compounds and compositions for use in modulation of small non-coding rnas. Isis Pharmaceuticals, Esau Christine, Lollo Bridget, Bennett C Frank, Freier Susan M, Griffey Richard H, Baker Brenda F, Vickers Timothy, Marcusson Eric G, Koller Erich, Swayze Eric E, Jain Ravi, Bhat Balkrishen, Peralta Eigen, LEGAARD Paul K, February 17, 2005: WO/2005/013901 (106 worldwide citation)

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targ ...


2
Bennett C Frank, Dean Nicholas M, Kole Ryszard, Kopczynski Casey C: Chimeric oligomeric compounds for modulation of splicing. Isis Pharmaceuticals, Bennett C Frank, Dean Nicholas M, Ercole Biotech, Kole Ryszard, Kopczynski Casey C, FULLER Michael L, March 8, 2007: WO/2007/028065 (65 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulati ...


3
Griffey Richard H, Bennett C Frank, Ecker David J, Ward Donna T, Freier Susan M: Microrna as ligands and target molecules. Isis Pharmaceuticals, Griffey Richard H, Bennett C Frank, Ecker David J, Ward Donna T, Freier Susan M, LEGAARD Paul K, March 17, 2005: WO/2005/023986 (17 worldwide citation)

The present invention provides methods for the identification of target molecules that bind to ligands, particularly microRNA ligands and mimics thereof and/or microRNA target molecules and mimics thereof, with as little as milliniolar (mM) affinity using mass spectrometry. The methods may be used t ...


4
Bennett C Frank, Chajut Ayelet, Esau Christine, Marcusson Eric G, Yerushalmi Noga: Targeting micrornas for the treatment of liver cancer. Isis Pharmaceuticals, Rosetta Genomics, Bennett C Frank, Chajut Ayelet, Esau Christine, Marcusson Eric G, Yerushalmi Noga, PUTKEY Frances R, May 7, 2009: WO/2009/058907 (12 worldwide citation)

Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such co ...


5
Bhanot Sanjay, Dobie Kenneth W, Freier Susan M, Dean Nicholas M, Bennett C Frank: Modulation of glucocorticoid receptor expression. Isis Pharmaceuticals, Bhanot Sanjay, Dobie Kenneth W, Freier Susan M, Dean Nicholas M, Bennett C Frank, BAK Mary E, August 4, 2005: WO/2005/071080 (11 worldwide citation)

Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and ...


6
BENNETT C FRANK: Compositions and methods for modulation of smn2 splicing in a subject. Isis Pharmaceuticals, Pauling David C, December 23, 2010: WO/2010/148249 (9 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.


7
Bennett C Frank, Vickers Timothy A: Oligonucleotide compositions and methods for the modulation of the expression of b7 protein. Isis Pharmaceuticals, November 24, 1999: EP0957926-A1 (6 worldwide citation)

Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic aci ...


8
Monia Brett P, Bennett C Frank, Gaarde William A, Lockhart Trisha, Mckay Robert: Compositions and their uses directed to hepcidin. Isis Pharmaceuticals, Monia Brett P, Bennett C Frank, Gaarde William A, Lockhart Trisha, Mckay Robert, HART Daniel, October 25, 2007: WO/2007/120883 (6 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for increasing red blood cell count in an ...


9
HASTINGS Michelle L, RIGO Frank, BENNETT C Frank: COMPOSÉS ANTISENS CIBLANT DES GÈNES ASSOCIÉS AU SYNDROME DE USHER, ANTISENSE COMPOUNDS TARGETING GENES ASSOCIATED WITH USHER SYNDROME. ISIS PHARMACEUTICALS, HASTINGS Michelle L, RIGO Frank, BENNETT C Frank, GINGRICH Brenden, November 8, 2012: WO/2012/151324 (6 worldwide citation)

The present invention provides compounds comprising oligonucleotides complementary to an Usher transcript. Certain such compounds are useful for hybridizing to an Usher transcript, including but not limited, to an Usher transcript in a cell. In certain embodiments, such hybridization results in modu ...


10
Bennett C Frank, Dobie Kenneth W, Freier Susan M, Crooke Stanley T: Compositions and methods for modulation of lmna expression. Isis Pharmaceuticals, Bennett C Frank, Dobie Kenneth W, Freier Susan M, Crooke Stanley T, FULLER Michael L, April 26, 2007: WO/2007/047913 (6 worldwide citation)

Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and ...



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