1
Bender Steven Lee, Broka Chris Allen, Campbell Jeffrey Allen, Castelhano Arlindo Lucas, Fisher Lawrence Emerson, Hendricks Robert Than, Sarma Keshab: Matrix metalloprotease inhibitors. Hoffmann La Roche, Agouron Pharma, June 25, 1997: EP0780386-A1 (167 worldwide citation)

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocy ...


2
Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


3
Chu Shao Song, Alegria Larry Andrew, Bender Steven Lee, Benedict Suzanne Pritchett, Borchardt Allen J, Kania Robert Steven, Nambu Mitchell David, Tempczyk Russell Anna Maria, Sarshar Sepehr, Bhumralkar Dilip, Peng Zhengwei, Yang Yi Michelle: Diaminothiazoles and their use for inhibiting protein kinases. Agouron Pharmaceuticals, PINO Mark J, December 14, 2000: WO/2000/075120 (4 worldwide citation)

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell ...


4
Kania Robert Steven, Bender Steven Lee, Borchardt Allen J, Braganza John F, Cripps Stephan James, Hua Ye, Johnson Michael David, Johnson Theodore Otto Jr, Luu Hiep The, Palmer Cynthia Louise, Reich Siegfried Heinz, Tempczyk Russell Anna Maria, Teng Min, Thomas Christine, Varney Michael David, Wallace Michael Brennan, Collins Michael Raymond: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, PINO Mark J, January 11, 2001: WO/2001/002369 (3 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


5
Fletcher Jr George Leland, Bender Steven Lee, Wadsworth Donald Harols: Oxoindolizine and oxoindolizinium dyes and processes for their preparation.. Eastman Kodak Co, January 5, 1983: EP0068876-A1 (2 worldwide citation)

Oxoindolizine and oxoindolizinium dyes are novel compounds useful in image formation such as in laser recording and reading. The dyes are formed by (1) the reaction of a cyclopropenone compound with a pyridine compound and optionally (2) by reaction of the product from (1) with a color-forming compo ...


6
Bender Steven Lee, Bhumralkar Dilip, Collins Michael Raymond, Cripps Stephan James, Deal Judith Gail, Nambu Mitchell David, Palmer Cynthia Louise, Peng Zhengwei, Varney Michael David, Jia Lei: Amide compounds for inhibiting protein kinases. Agouron Pharmaceuticals, GADIANO Christina, July 26, 2001: WO/2001/053274 (2 worldwide citation)

Amide compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invent ...


7
Collins Michael Raymond, Tempczyk Russell Anna Maria, Hua Ye, Johnson Michael David, Bender Steven Lee, Kania Robert Steven, Borchardt Allen J, Braganza John F, Cripps Stephan James, Johnson Theodore Otto Jr, Luu Hiep The, Palmer Cynthia Louise, Reich Siegfried Heinz, Teng Min, Thomas Christine, Varney Michael David, Wallace Michael Brennan: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharma, January 11, 2006: EP1614683-A1 (1 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


8
BENDER STEVEN LEE, CASPERSON GERALD FRIES, HU LOWE DANA DAN, JIANG XIN, LI GANG, NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT, BRAMS PETER, HUANG HAICHUN, DEVAUX BRIGITTE, CHEN HAIBIN, TANAMACHI DAWN, TOY KRISTOPHER, YANG LAN, SPROUL TIM W, YAMANAKA MARK: [fr] Anticorps Alpha 5 - beta 1 et leurs utilisations, [de] Alpha-5-Beta-1-Antikörper und ihre Verwendungen, [en] Alpha 5 - beta 1 antibodies and their uses. SQUIBB BRISTOL MYERS CO, Pfizer, September 25, 2013: EP2641612-A1

[en] The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin +-51 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host c ...


9
BENDER STEVEN LEE, CASPERSON GERALD FRIES, HU LOWE DANA DAN, JIANG XIN, LI GANG, NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT, BRAMS PETER, HUANG HAICHUN, DEVAUX BRIGITTE, CHEN HAIBIN, TANAMACHI DAWN, TOY KRISTOPHER, YANG LAN, SPROUL TIM W, YAMANAKA MARK: [fr] Anticorps Alpha 5 - bêta 1 et leurs utilisations, [de] Alpha-5-beta-1-Antikörper und deren Verwendungen, [en] Alpha 5 - beta 1 antibodies and their uses. SQUIBB BRISTOL MYERS CO, Pfizer, October 16, 2013: EP2650017-A2

[en] The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin +-51 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host c ...


10
Guo Chuangxing, Augelli Szafran Corinne E, Barta Nancy Sue, Bender Steven Lee, Bigge Christopher Franklin, Caprathe Bradley William, Chatterjee Arindam, Deal Judith, Dong Liming, Fay Lorraine Kathleen, Hou Xinjun, Hudack Raymond Andrew Jr: Heterobicycles fkbp-ligands. Agouron Pharma, June 2, 2004: EP1423119-A1

Diazabicyclo[3.3.1]nonane derivatives that inhibit the peptidyl-prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described for treating neurological disorders. Also described are compounds useful for preparing such inhibitors.