1
Barry L Karger, Frantisek Foret, Paul M Zavracky, E Nicol McGruer, Qifeng Xue, Yuriy M Dunayevskiy: Microscale fluid handling system. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, February 16, 1999: US05872010 (323 worldwide citation)

A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices for further off-chip sample manipulation and analysis is ...


2
Dallas E Hughes, Barry L Karger, James L Waters, Yuriy M Dunayevskiy: Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry. Cetek Corporation, Weingarten Schurgin Gagnebin & Lebovici, August 13, 2002: US06432651 (63 worldwide citation)

This invention combines a capillary electrophoresis (CE) technique for screening complex biological samples with mass spectrometry (MS), to provide a streamlined procedure for identifying and characterizing candidate ligands in a complex biological sample that bind at a selected binding strength to ...


3
Barry L Karger, Aharon S Cohen: Capillary gel electrophoresis columns. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, September 12, 1989: US04865707 (48 worldwide citation)

An improved microcapillary column for high performance electrophoresis includes a microcapillary, a hydrophilic polymer within a gel of crosslinked polyacrylamide polymerized in the tube, and preferably, a thin layer of connecting material covalently bonded to the inner surface of the microcapillary ...


4
Barry L Karger, Aharon Cohen: High performance microcapillary gel electrophoresis. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, September 12, 1989: US04865706 (45 worldwide citation)

A microcapillary column for high performance electrophoresis includes a fused silica microcapillary, a gel of crosslinked polyacrylamide polymerized in the tube, and a thin layer of connecting material covalently bonded to the inner surface of the microcapillary wall and to the polymeric gel. The ge ...


5
Barry L Karger, Aharon Cohen: High performance microcapillary gel electrophoresis. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, March 5, 1991: US04997537 (42 worldwide citation)

A microcapillary column for high performance electrophoresis. A preferred column includes a microcapillary, a thin layer of coating material covalently bonded to the inner surface of the microcapillary wall, a thin layer of a hydrophilic polymer absorbed on the layer of coating material, and a gel c ...


6
Barry L Karger, Frantisek Foret, Jan Preisler: On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, January 16, 2001: US06175112 (38 worldwide citation)

A universal interface for continuous on-line liquid sample introduction directly to the time-of-flight mass spectrometer, which can further promote throughput and utility of MALDI-TOF MS, is disclosed. Preferably, the liquid sample includes a matrix, either solid or liquid, for use in matrix-assiste ...


7
Barry L Karger, Robert J Nelson: Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, February 4, 1992: US05085757 (35 worldwide citation)

An integrated temperature control/alignment system for use with a high performance capillary electrophoretic apparatus comprises a complementary pair of capillary column mounting plates formed from an electrically insulative, high thermal conductivity material for mounting a capillary column. The fi ...


8
Barry L Karger, Kiyohito Shimura: Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, September 20, 1994: US05348633 (33 worldwide citation)

A method for quantitative detection of trace amounts of an analyte in a sample is disclosed. The method in the preferred embodiment includes providing an Fab' fragment of an immunoglobulin labelled at a reactive sulfhydryl group with a fluorescent dye; combining the labelled Fab' fragment with a sam ...


9
Barry L Karger, Aharon S Cohen, David N Heiger: Pulsed field capillary electrophoresis. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, June 16, 1992: US05122248 (32 worldwide citation)

Apparatus and method for conducting electrophoresis in a capillary tube under the influence of a pulsed electric field. Apparatus for separating and detecting molecular species of a sample in a conductive medium includes a capillary tube for containing conductive medium, means for introducing a samp ...


10
Andras Guttman, Chia Hui Shieh, Barry L Karger, Stephen J Pentoney Jr, Kenneth D Konrad, Sushma Rampal, Katalin Ganzler: Capillary column containing removable separation gel composition and method of use. Beckman Instruments, William H May, P R Harder, Janis C Henry, December 6, 1994: US05370777 (31 worldwide citation)

Disclosed herein are capillary columns for capillary electrophoretic analysis of sample constituents. In an embodiment, the columns comprise a bifunctional layer comprising a positively charged amine group adsorbed to the inner wall of the capillary and an active functional group; a gel composition; ...