1
Kyriacos A Athanasiou, Barbara D Boyan: Continuous release polymeric implant carrier. The University of Texas System, Greenlee Winner and Sullivan P C, January 11, 2000: US06013853 (189 worldwide citation)

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts ...


2
Allan G A Coombes, James D Heckman, Barbara D Boyan: Process of making a resorbable implantation device. Board of Regents The University of Texas System, Arnold White & Durkee, March 1, 1994: US05290494 (169 worldwide citation)

Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be v ...


3
Kyriacos A Athanasiou, Barbara D Boyan: Biodegradable implant. Board of Regents University of Texas System, Greenlee Winner and Sullivan P C, March 2, 1999: US05876452 (164 worldwide citation)

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts ...


4
Kyriacos A Athanasiou, Barbara D Boyan: Multi-phase bioerodible implant/carrier and method of manufacturing and using same. Board of Regents University of Texas System, Greenlee and Winner, March 4, 1997: US05607474 (138 worldwide citation)

A carrier and method of manufacturing and using the same is provided for receiving supporting replenished tissue growing into a diseased or damaged area within a physiological system. The carrier can be implanted in the interface region between tissue having different mechanical properties to suppor ...


5
Barbara D Boyan, Chandra M Agrawal, James D Heckman: Biodegradable implant for fracture nonunions. Board of Regents Univ of Texas System, Greenlee and Winner, February 20, 1996: US05492697 (132 worldwide citation)

A biodegradable implant for placement in nonunion bone fractures as a substitute for bone graft material is provided which is a flat plate or disk having a thickness of between about 1 mm and about 15% of the length of the bone, interconnected micropores, and canals substantially equivalent in size ...


6
Barbara D Boyan, Gabriele Niederauer, Kristine Kieswetter, Neil C Leatherbury, David C Greenspan: Biodegradable implant material comprising bioactive ceramic. OsteoBiologics, USBiomaterials Corporation, Greenlee Winner and Sullivan P C, November 2, 1999: US05977204 (129 worldwide citation)

Biodegradable polymeric therapeutic implant materials incorporating bioactive ceramics such as Bioglass.RTM. ceramic are provided. These implants provide increased mechanical properties and pH control, enabling the use of these materials to design porous and nonporous therapeutic implants used as ce ...


7
Barbara D Boyan, Zvi Schwartz: Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor. OsteoBiologics, Greenlee Winner and Sullivan, December 14, 1999: US06001352 (79 worldwide citation)

A method for stimulating chondrocyte proliferation and inhibiting chondrocyte differentiation along the endochondral developmental pathway is provided comprising contacting condrocytes with an effective amount of Platelet-Derived Growth Factor (PDGF) such as PDGF-BB, PDGF-AA OR PDGF-AB in the substa ...


8
Barbara D Boyan, Stephen J Kennedy: Method of making hydrogel implants. Georgia Tech Research Corporation, Knobbe Martens Olson & Bear, March 23, 2010: US07682540 (54 worldwide citation)

Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bear ...


9
Allan G A Coombes, James D Heckman, Barbara D Boyan: Resorbable materials based on independently gelling polymers of a single enantiomeric lactide. Board of Regents The University of Texas System, Anold White & Durkee, March 14, 1995: US05397572 (29 worldwide citation)

Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be v ...


10
Barbara D Boyan, Zvi Schwartz, Lynda F Bonewald: Activation of latent transforming growth factor .beta. by matrix vesicles. Board of Regents the University of Texas System, Greenlee Winner and Sullivan P C, August 12, 1997: US05656450 (23 worldwide citation)

A latent growth factor such as transforming growth factor beta (TGF.beta.) is converted to active form by matrix vesicles or an extract from matrix vesicles. The matrix vesicles may be stimulated with a Regulator of Enhancing Factor (REF) such as 1,25-dihydroxy vitamin D (1,25-(OH).sub.2 D.sub.3) or ...