1
Thomas E Rogers, Steven H Gray, Balekudru Devadas, Steven P Adams: Improved probes using nucleosides containing 3-dezauracil analogs. Monsanto Company, Dennis A Bennett, July 28, 1992: US05134066 (253 worldwide citation)

The deazauracil containing probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.


2
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan R Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz: Substituted benzopyran derivatives for the treatment of inflammation. G D Searle & Co, Joseph W Bulock, March 7, 2000: US06034256 (41 worldwide citation)

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.


3
John J Talley, James A Sikorski, Bryan H Norman, Roland S Rogers deceased, Balekudru Devadas, Matthew J Graneto, Jeffery S Carter: Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors. G D Searle & Co, Joseph W Bulock, July 1, 1997: US05643933 (25 worldwide citation)

This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.


4
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran analogs for the treatment of inflammation. G D Searle & Co, Joseph W Bulock, June 20, 2000: US06077850 (23 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.su ...


5
Balekudru Devadas, John Walker, Shaun R Selness, Terri L Boehm, Richard C Durley, Rajesh Devraj, Brian S Hickory, Paul V Rucker, Kevin D Jerome, Heather M Madsen, Edgardo Alvira, Michele A Promo, Radhika M Blevis Bal, Laura D Marruto, Jeff Hitchcock, Thomas Owen, Win Naing, Li Xing, Huey S Shieh, Aruna Sambandam, Shuang Liu, Ian L Scott, Kevin F McGee: Substituted pyridinones. Pharmacia Corporation, Julie M Lappin, Charles Ashbrook, June 27, 2006: US07067540 (22 worldwide citation)

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions con ...


6
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran derivatives for the treatment of inflammation. G D Searle & Co, James M Warner, Joseph W Bulock, August 7, 2001: US06271253 (19 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′


7
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran analogs for the treatment of inflammation. G D Searle & Co, McDonnell Boehnen Hulbert & Berghoff, December 10, 2002: US06492390 (14 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′


8

9
John J Talley, James A Sikorski, Matthew J Graneto, Jeffrey S Carter, Bryan H Norman, Balekudru Devadas, Hwang Fun Lu: Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors. Pharmacia Corporation, Senniger Powers Leavitt & Roedel, August 13, 2002: US06432999 (13 worldwide citation)

This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.


10
Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Nagarajan, Joseph J McDonald: Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors. G D Searle & Co, Frank S Ungemach, January 6, 1998: US05705500 (11 worldwide citation)

Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, c ...



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