1
Waclaw J Rzeszotarski, Babu J Mavunkel: Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists. Nova Pharmaceutical Corporation, Breneman & Georges, December 26, 1989: US04889860 (84 worldwide citation)

A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a longacting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or allyl, and R.sub.1 is an unsubstituted or substitut ...


2
Waclaw J Rzeszotarski, Babu J Mavunkel: Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists. Nova Pharmaceutical Corporation, Breneman & Georges, July 26, 1988: US04760069 (75 worldwide citation)

A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a long-acting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or allyl, and R.sub.1 is an unsubstituted or substitu ...


3
Babu J Mavunkel, John A Lewicki, David Y Liu, George F Schreiner: Compounds and methods to treat cardiac failure and other disorders. Scios, Morrison & Foerster, October 10, 2000: US06130235 (51 worldwide citation)

The invention is directed to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Ar.sup.1 is indole, benzimidazole, or benzotriazole, optionally substituted with lower alkyl (1-4C), halo, or lower alkoxy (1-4C);


4
Babu J Mavunkel, David Y Liu, George F Schreiner, John A Lewicki, John J Perumattam: Compounds and methods to treat cardiac failure and other disorders. Scios, Morrison & Foerster, July 8, 2003: US06589954 (35 worldwide citation)

Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure and in treati ...


5
Babu J Mavunkel, Sarvajit Chakravarty, John J Perumattam, Sundeep Dugar, Qing Lu, Xi Liang: Indole-type derivatives as inhibitors of p38 kinase. Scios, Morrison & Foerster, March 15, 2005: US06867209 (24 worldwide citation)

The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein represents a single or double bond; one Z2 is CA or CR8A and the other is CR1, CR12, NR6 or N wherein each R ...


6
R Richard Goehring, Babu J Mavunkel, David Y Liu, George F Schreiner, Gregory Leudtke, John A Lewicki: Inhibitors of p38-a kinase. Scios, Morrison & Foerster, April 1, 2003: US06541477 (18 worldwide citation)

The invention is directed to methods for treating conditions mediated by by P38&agr; kinase using compounds of the formula


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Richard J Sundberg, Daniel J Dahlhausen, Govindarajan Manikumar, Babu J Mavunkel, Hikmat A Musallam, Atanu Biswas, Srinivasan Varadarajan: Compounds exhibiting anti-parasitic activity and a method for their use. The United States of America represented by the Secretary of the Army, Werten F W Bellamy, John Francis Moran, April 20, 1993: US05204352 (8 worldwide citation)

Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a lin ...