1
Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P Mickey Williams, William I Wood, Daniel Yansura: IL-17 homologous polypeptides and therapeutic uses thereof. Genentech, Elizabeth M Barnes, May 27, 2003: US06569645 (27 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


2
Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P Mickey Williams, William I Wood, Daniel Yansura: IL-17 related mammalian cytokine polypeptides (IL-17E). Genentech, Elizabeth M Barnes, June 17, 2003: US06579520 (24 worldwide citation)

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising t ...


3
Nico P Ghilardi, Frederic J de Sauvage, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin Gurney, William I Wood: Nucleic acid encoding novel type-1 cytokine receptor GLM-R. Genentech, Craig G Svoboda, December 4, 2007: US07303896 (23 worldwide citation)

The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypep ...


4
Austin Gurney, John Lewicki, Sanjeev Satyal, Timothy Hoey: Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth. OncoMed Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, May 25, 2010: US07723477 (18 worldwide citation)

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present i ...


5
John A Lewicki, Austin Gurney, Timothy Hoey, Wan Ching Yen, Sanjeev Satyal: Antibodies to notch receptors. OncoMed Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, April 5, 2011: US07919092 (17 worldwide citation)

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present i ...


6
Austin Gurney: Compositions and methods for treating and diagnosing cancer. OncoMed Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, April 17, 2012: US08158758 (17 worldwide citation)

The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as a ...


7
Jian Chen, Ellen Filvaroff, Audrey Goddard, Austin Gurney, Hanzhong Li, William I Wood: IL-17 homologous polypeptides and therapeutic uses thereof. Genentch, Sidley Austin, October 3, 2006: US07115398 (16 worldwide citation)

The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides o ...


8
Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, William I Wood: Receptor for IL-17 homologous polypeptides and uses thereof. Genentech, Sidley Austin, Elizabeth Barnes, August 14, 2007: US07256264 (15 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


9
Austin Gurney, Fumiko Axelrod, Tim Hoey, Sanjeev Satyal: Anti-human DLL4 antibodies and compositions. OncoMed Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, July 6, 2010: US07750124 (14 worldwide citation)

An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.


10
Michael F Clarke, Tim Hoey, Xinhao Wang, Scott Dylla, Austin Gurney, Piero Dalerba, Mark Prince, Grace Chen: Compositions and methods for treating and diagnosing cancer. The Regents of the University of Michigan, OncoMed Pharmaceuticals, Casimir Jones SC, May 25, 2010: US07723112 (13 worldwide citation)

The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of can ...