1
Felix Theeuwes, Atul D Ayer: Osmotic system having laminar arrangement for programming delivery of active agent. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, February 22, 1977: US04008719 (641 worldwide citation)

An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a la ...


2
Atul D Ayer, Felix Theeuwes: Osmotic system with distribution zone for dispensing beneficial agent. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, April 29, 1980: US04200098 (415 worldwide citation)

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned ...


3
Atul D Ayer, Felix Theeuwes: Process for manufacturing device with dispersion zone. Alza Corporation, Paul L Sabatine, Edward L Mandell, August 25, 1981: US04285987 (384 worldwide citation)

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned ...


4
Atul D Ayer, Felix Theeuwes: Therapeutic device for osmotically dosing at controlled rate. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, July 3, 1979: US04160020 (252 worldwide citation)

An osmotic device is disclosed for delivering an active agent. The device comprises a wall surrounding a compartment with a passageway through the wall for releasing the agent. The wall comprises a material permeable to an external fluid and substantially impermeable to agent and at least one additi ...


5
Felix Theeuwes, Atul D Ayer: Osmotic devices having composite walls. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, March 7, 1978: US04077407 (226 worldwide citation)

An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding a compartment and has a passageway through the wall for releasing the agent. The wall is formed of a multiplicity of materials comprising a material permeable to an external fluid and substan ...


6
Sonya Merrill, Atul D Ayer, Paul Hwang, Anthony L Kuczynski: Morphine therapy. Alza Corporation, Paul L Sabatine, Felissa H Cagan, Richard T Ito, October 24, 1995: US05460826 (137 worldwide citation)

A bilayer comprising a morphine layer of morphine, poly(alkylene oxide) and poly(vinylpyrrolidone); and an expandable contacting layer of coated granules of a higher molecular weight poly(alkylene oxide) and a hydroxyalkylcellulose, which bilayer is disclosed for morphine therapy. A method is disclo ...


7
Felix Theeuwes, Atul D Ayer: Laminated osmotic system for dispensing beneficial agent. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, March 29, 1977: US04014334 (132 worldwide citation)

An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a se ...


8
Andrew C Lam, Padmaja Shivanand, Atul D Ayer, Richard G Weyers, Suneel K Gupta, Diane R Guinta, Carol A Christopher, Samuel R Saks, Lawrence G Hamel, Jeri D Wright, Zahedeh Hatamkhany: Methods and devices for providing prolonged drug therapy. Alza Corporation, Woodcock Washburn, July 19, 2005: US06919373 (126 worldwide citation)

Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additi ...


9
Patrick S L Wong, Felix Theeuwes, George V Guittard, Atul D Ayer: Method of therapy comprising an osmotic caplet. Alza Corporation, Paul L Sabatine, Susan K Thomas, Michael J Rafa, February 9, 1999: US05869097 (79 worldwide citation)

An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.


10
Sonya Merrill, Atul D Ayer, Paul Hwang, Anthony L Kuczynski: Morphine therapy. ALZA Corporation, Paul L Sabatine, Mary A Dillahunty, Felissa H Cagan, January 14, 1997: US05593695 (78 worldwide citation)

A therapeutic tablet comprising morphine, poly(alkylene oxide) and poly(vinylpyrrolidone) encased by a composition comprising a cellulose polymer.