1
Alexander L Weis, Ashis K Saha, Frederick H Hausheer: Process of linking nucleosides with a siloxane bridge. Sterling Winthrop, Irving Newman, May 25, 1993: US05214134 (250 worldwide citation)

A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucle ...


2
Ashis K Saha, Christopher J Burns, Alfred M Del Vecchio, Thomas R Bailey, Jason A Reinhardt, Bheemashankar A Kulkarni, Thomas H Faitg, Hao Feng, Susan R Rippin, Charles W Blackledge, David J Rys, Thomas A Lessen, John Swestock, Yijun Deng, Theodore J Nitz: Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases. ViroPharma Incorporated, Wyeth, Patrick J Hagan Esq, Dann Dorfman Herrell and Skillman P C, September 4, 2007: US07265152 (36 worldwide citation)

The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by ...


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Madhusudhan R Gowravaram, Jeffrey Johnson, Ewell R Cook, Robert C Wahl, Alan M Mathiowetz, Bruce E Tomczuk, Ashis K Saha: Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof. Sterling Winthrop, William J Davis, Paul E Dupont, May 7, 1996: US05514716 (13 worldwide citation)

This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of matrix metall ...


5
Madhusudhan R Gowravaram, Jeffrey Johnson, Ewell R Cook, Robert C Wahl, Alan M Mathiowetz, Bruce E Tomczuk, Ashis K Saha: Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof. Sanofi, William J Davis, Paul E Dupont, April 8, 1997: US05618844 (9 worldwide citation)

This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of matrix metall ...


6
Ashis K Saha, Christopher J Burns, Alfred M Del Vecchio, Thomas R Bailey, Jason A Reinhardt, Bheemashankar A Kulkarni, Thomas H Faitg, Hao Feng, Susan R Rippin, Charles W Blackledge, David J Rys, Thomas A Lessen, John Swestock, Yijun Deng, Theodore J Nitz: Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases. ViroPharma Incorporated, Wyeth, Dann Dorfman Herrell and Skillman, Patrick J Hagan, February 23, 2010: US07666863 (8 worldwide citation)

The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the he ...


7
John L Toner, David A Hilborn, Bruce J Murray, Timothy Z Hossain, Robert A Snow, Ashis K Saha, Richard Philion, Clyde W Shearman, Chandra Shah: Pyridine complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions. Nycomed Imaging, Fish & Richardson P C, January 13, 1998: US05707603 (3 worldwide citation)

The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agent ...


8
Scott Kevin Thompson, Roger Astbury Smith, Sandeep Gupta, Tony Priestley, Nicholas James Laping, Ashis K Saha, Sonali Rudra: Cyclohexylamines. Endo Pharmaceuticals, RatnerPrestia, April 1, 2014: US08685418 (2 worldwide citation)

The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include adminis ...


9
Ashis K Saha, Malcolm J Kavarana, Ghotas Evindar, Alexander L Satz, Barry Morgan: Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity. Praecis Pharmaceuticals, Lahive & Cockfield, Giulio A DeConti, Maria Laccotripe Zacharakis, July 10, 2007: US07241812 (1 worldwide citation)

The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.


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Efrat Ben Zeev, Vincent Jacques, Yael Marantz, A Sekar Reddy, Zhaoda Zhang, Oren Becker, Dilara McCauley, Pini Orbach, Sharon Shacham, Ashis K Saha, Michael Xie: Adenosine analogs and their use. Microdose Therapeutx, Hayes Soloway P C, October 29, 2013: US08569259 (1 worldwide citation)

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, ...