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Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (63 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


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Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


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Okano Kazuo, Miyazawa Shuhei, Clark Richard Stephen John, Abe Shinya, Kawahara Tetsuya, Shimomura Naoyuki, Asano Osamu, Yoshimura Hiroyuki, Miyamoto Mitsuaki, Sakuma Yoshinori, Muramoto Kenzo, Obaishi Hiroshi, Harada Koukichi, Tsunoda Hajime, Katayama Satoshi, Yamada Kouji, Souda Shigeru, Machida Yoshimasa, Katayama Kouichi: 1,4-diazepine derivative and its pharmaceutical use.. Eisai, May 9, 1990: EP0367110-A1 (31 worldwide citation)

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X ...


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Christ William J, Kawata Tsutomu, Hawkins Lynn D, Kobayashi Seiichi, Asano Osamu, Rossignol Daniel P: Anti-endotoxin compounds.. Eisai, April 14, 1993: EP0536969-A2 (17 worldwide citation)

Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.


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Juengst Stefan Dr, Maekawa Kouichiro, Asano Osamu, Heider Juergen Dr: Ceramic discharge vessel for high-pressure lamps, method of manufacturing same, and related sealing material.. Patra Patent Treuhand, NGK Insulators, August 10, 1994: EP0609477-A1 (14 worldwide citation)

A ceramic discharge vessel (8) for a high-pressure discharge lamp has a pin-like feedthrough (10) inserted in a plug (11) made from a composite material. The feedthrough (10) has been sintered directly into the plug (11) and is additionally sealed by covering the area, surrounding the feedthrough, o ...


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Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


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Harada Hitoshi, Asano Osamu, Ueda Masato, Miyazawa Shuhei, Kotake Yoshihiko, Kabasawa Yasuhiro, Yasuda Masahiro, Yasuda Nobuyuki, Iida Daisuke, Nagakawa Junichi, Hirota Kazuo, Nakagawa Makoto: Pyrimidine compound and medicinal composition thereof. Eisai, July 21, 2004: EP1439175-A1 (11 worldwide citation)

The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R and R are the same as ...


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Harada Hitoshi, Asano Osamu, Miyazawa Shuhei, Ueda Masato, Yasuda Masahiro, Yasuda Nobuyuki: 2-aminopyridine compounds and use thereof as drugs. Eisai, May 7, 2003: EP1308441-A1 (10 worldwide citation)

The present invention provides 2-aminopyridine compound having an excellent adenosine receptor (A1, A2a, A2b receptors) antagonism, which is represented by the following formula: (wherein, R represents cyano group, carboxyl group or an optionally substituted carbamoyl group; R represents hydrogen at ...


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Sato Takashi, Okamoto Yasushi, Asano Osamu, Watanabe Nobuhisa, Nagakura Tei, Saeki Takao, Inoue Atsushi, Sakurai Masahiro: Amidine derivative, anticoagulant agent given by using the same, and remedy for thrombosis. Eisai, July 30, 2003: JP2003-212837 (6 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new amidine derivative having serine protease-inhibiting activity, particularly excellent in blood coagulation factor VIIa-inhibiting activity, to provide a pharmaceutically acceptable salt thereof, to provide a solvate thereof, to provide a blood coagulation facto ...