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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Maruyama Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kobayashi Kenji, Uda Hideyuki, Morikawa Maki: Catecholpropionic acid derivative and nuclear receptor agonist containing the same as active ingredient. Mitsui Chemicals, September 26, 2001: JP2001-261612 (11 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for various kinds of diseases, e.g. diabetes mellitus, hyperlipidemia, arteriosclerosis, etc., by activating peroxisome proliferator-activated receptor(PPAR)-α or -γ which is a nuclear transcription factor and relates to the disease ...


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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Nagase Hiroshi, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Yamaki Toshifumi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki: Quinoline derivatives and medicinal use thereof. Mitsui Chemicals, December 18, 2002: EP1266888-A1 (6 worldwide citation)

A quinoline derivative represented by the following formula (1): allows PPAR alpha or gamma which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various ...


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Asada Noriaki, Honjo Masaru, Kamioka Takeshi, Ikeda Miwa, Horikomi Kazutoshi: Human growth hormone agent for adults. Mitsui Toatsu Chemicals, January 15, 1997: EP0753307-A2 (2 worldwide citation)

Use of an effective amount of a particular authentic human growth hormone having a molecular weight of 20,000 daltons to human adults is disclosed which improves body composition, stimulates lipolysis, increases serum insulin-like growth factor I and can be used in replacement therapy for human grow ...


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ASADA NORIAKI, AOKI SHINYA, NARUSE HIROSHI, MIYAKOSHI SHOICHI, ARATA MASAMI: COMPOSITION POUR LA RÉPARATION DE TISSUS OSSEUX, ZUSAMMENSETZUNG ZUR REPARATUR VON HARTEM GEWEBE, COMPOSITION FOR HARD TISSUE REPAIR. Mitsui Chemicals, September 26, 2012: EP2502638-A1

The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth) acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron ...


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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki: Benzothiophene derivatives and medicinal use thereof. Mitsui Chemicals, February 19, 2003: EP1284265-A1

A benzothiophene derivative represented by formula (1): can activate a peroxisome proliferator-activated receptor (PPAR) alpha or gamma which is an intranuclear transcription factor. The compound may be used as an active ingredient to give a drug for preventing or treating a variety of diseases invo ...


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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Nagase Hiroshi, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Yamaki Toshifumi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki: Quinoline derivatives and medicinal use thereof. Mitsui Chemicals, Tsunoda Hidetoshi, Fukazawa Nobuyuki, Nagase Hiroshi, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Yamaki Toshifumi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki, KANEDA Nobuyuki, September 27, 2001: WO/2001/070698

Quinoline derivatives represented by the general formula (1) which strongly agonize a nuclear transcription factor PPAR$g(a) or $g(g) and have a low toxicity. By using these compounds as the active ingredient, preventives or remedies for various diseases in which PPAR$g(a) or $g(g) participates can ...


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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki: Benzothiophene derivatives and medicinal use thereof. Mitsui Chemicals, Tsunoda Hidetoshi, Fukazawa Nobuyuki, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki, KANEDA Nobuyuki, September 27, 2001: WO/2001/070723

Drugs containing as the active ingredient benzothiophene derivatives represented by the following general formula (1), which have an effect of activating peroxosome proliferator-activated receptor (PPAR) $g(a) or $g(g) (i.e., nuclear transcriptional factors) to thereby prevent or treat various disea ...


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ASADA Noriaki, NARUSE Hiroshi: 軟組織用接着剤組成物、創傷被覆用接着剤組成物又は創傷被覆材組成物, COMPOSITION ADHÉSIVE POUR TISSU MOU, ET COMPOSITION DE PANSEMENT ADHÉSIVE OU COMPOSITION DE PANSEMENT, ADHESIVE COMPOSITION FOR SOFT TISSUE, AND WOUND-DRESSING ADHESIVE COMPOSITION OR WOUND-DRESSING COMPOSITION. Mitsui Chemicals, ASADA Noriaki, NARUSE Hiroshi, SSINPAT PATENT FIRM, November 22, 2012: WO/2012/157478

[Problem] To provide an adhesive composition for soft tissue and a wound-dressing adhesive composition or wound-dressing composition having not only low toxicity, low hazardousness, and high adhesive strength, but also excellent ease of handling during coating, and furthermore endowing the resulting ...


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ASADA Noriaki, SASAKI Kenju, AOKI Shinya, NARUSE Hiroshi: 3成分混合装置および3成分混合キット, DISPOSITIF ET KIT DE MÉLANGE DE TROIS COMPOSANTS, DEVICE AND KIT FOR MIXING THREE COMPONENTS. Mitsui Chemicals, ASADA Noriaki, SASAKI Kenju, AOKI Shinya, NARUSE Hiroshi, SSINPAT PATENT FIRM, August 30, 2012: WO/2012/115022

[Problem] To provide a three-component mixing device with which anybody can mix three medical agents easily and uniformly when preparing a three-component mixed adhesive, for example, for a surgical or dental operation (treatment). [Solution] The three-component mixing device comprises: a syringe ha ...