1
Arthur M Krieg, Joel Kline, Dennis Klinman, Alfred D Steinberg: Immunostimulatory nucleic acid molecules. University of Iowa Research Foundation, Coley Pharmaceutical Group, The United States of America represented by the Department of Health and Human Services, Wolf Greenfield & Sacks P C, March 27, 2001: US06207646 (345 worldwide citation)

Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed.


2
Arthur M Krieg, Joel N Kline: Immunostimulatory nucleic acid molecules. University of Iowa Research Foundation, Coley Pharmaceutical Group, The United States of America represented by the Department of Health and Human Services, Wolf Greenfield & Sacks P C, May 29, 2001: US06239116 (329 worldwide citation)

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.


3
Heather L Davis, Joachim Schorr, Arthur M Krieg: Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant. University of Iowa Research Foundation, Coley Pharmaceutical, Ottawa Health Research Institute, Wolf Greenfield & Sacks P C, June 18, 2002: US06406705 (291 worldwide citation)

The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be ...


4
Arthur M Krieg, Dennis Klinman, Alfred D Steinberg: Immunomodulatory oligonucleotides. The University of Iowa Research Foundation, The United States of America, Coley Pharmaceutical Group, Wolf Greenfield & Sacks P C, February 27, 2001: US06194388 (238 worldwide citation)

Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinuc ...


5
Arthur M Krieg, Heather L Davis, Tong Wu, Joachim Schorr: Vectors and methods for immunization or therapeutic protocols. University of Iowa Research Foundation, Loeb Health Research Institute at the Ottawa Hospital, Coley Pharmaceutical, Wolf Greenfield & Sacks P C, January 15, 2002: US06339068 (230 worldwide citation)

The present invention shows that DNA vaccine vectors can be improved by removal of CpG-N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of expression, the optimized vector should include a promoter/enhancer that is not down-regulated by the cytokines indu ...


6
Arthur M Krieg, Gunther Hartmann: Immunostimulatory nucleic acid molecules for activating dendritic cells. University of Iowa Research Foundation, Wolf Greenfield & Sacks P C, August 6, 2002: US06429199 (219 worldwide citation)

The present invention relates generally to methods and products for activating dendritic cells. In particular, the invention relates to oligonucleotides which have a specific sequence including at least one unmethylated CpG dinucleotide which are useful for activating dendritic cells. The methods ar ...


7
Arthur M Krieg, George Weiner: Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines. University of Iowa Research Foundation, Wolf Greenfield & Sacks P C, April 17, 2001: US06218371 (183 worldwide citation)

The present invention relates to synergistic combinations of immunostimulatory CpG oligonucleotides and immunopotentiating cytokines. In particular, the invention relates to methods of stimulating an immune response using the synergistic combination of compounds and products related thereto.


8
Arthur M Krieg, David A Schwartz: Use of nucleic acids containing unmethylated CPC dinucleotide in the treatment of LPS-associated disorders. University of Iowa Research Foundation, Wolf Greenfield & Sacks P C, April 10, 2001: US06214806 (180 worldwide citation)

The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to treat pulmonary ...


9
Arthur M Krieg, George Weiher: Method of treating cancer using immunostimulatory oligonucleotides. University of Iowa Research Foundation, Wolf Greenfield & Sacks P C, November 25, 2003: US06653292 (110 worldwide citation)

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.


10
Gunther Hartmann, Robert L Bratzler, Arthur M Krieg: Methods related to immunostimulatory nucleic acid-induced interferon. Coley Pharmaceutical Group, University of Iowa Research Foundation, Coley Pharmaceutical, Wolf Greenfield & Sacks P C, September 27, 2005: US06949520 (80 worldwide citation)

Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In ...