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Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Recombinant immunoglobin preparations. Genentech, March 28, 1989: US04816567 (2766 worldwide citation)

Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglo ...


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Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Methods of producing immunoglobulins, vectors and transformed host cells for use therein. Genentech, Burns Doane Swecker & Mathis, December 18, 2001: US06331415 (344 worldwide citation)

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains o ...


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John M Corbett, Kenneth C Reed, Arthur D Riggs: Device and method for the automated cycling of solutions between two or more temperatures. Beckman Research Institute of the City of Hope, Christie Parker & Hale, December 14, 1993: US05270183 (162 worldwide citation)

The present invention provides an apparatus and method for the amplification of a particular sequence(s) of DNA in a sample using polymerased chain reaction. The method of the present invention involves the injection of a reaction mixture into a stream of carrier fluid. The carrier fluid then passes ...


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