1
Arnold J Levine, Thomas E Shenk, Cathy A Finlay: Methods of diagnosing pre-cancer or cancer states using probes for detecting mutant p53. The Trustees of Princeton University, Irving N Feit, Laura S Weiss, January 17, 1995: US05382510 (50 worldwide citation)

A panel of probes that detect and distinguish between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells, each set giving rise to a phenotype that is different from that of wild-type p53 and of at least one other set of p53 mutants.


2
Arnold J Levine, Maureen Elizabeth Murphy, David H Mack, Kurt Carlyle Gish, Edward Yat Wah Tom: P53-regulated genes. Affymetrix, Princeton University, Banner & Witcoff, February 1, 2000: US06020135 (43 worldwide citation)

Many genes are identified as being p53-regulated which were not heretofore known to be p53-regulated. This includes both genes whose expression is induced and genes whose expression is repressed by the expression of wild-type p53. Monitoring expression of these genes is used to provide indications o ...


3
David A Botstein, Robert L Cohen, Audrey D Goddard, Austin L Gurney, Kenneth J Hillan, David A Lawrence, Arnold J Levine, Diane Pennica, Margaret Ann Roy, William I Wood: WISP polypeptides and nucleic acids encoding same. Genentech, Diane L Marschang, May 14, 2002: US06387657 (8 worldwide citation)

Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides ...


4
Arnold J Levine, Cathy A Finlay, Carlos Cordon Cardo: Method for detecting pre-cancerous or cancerous cells using P90 antibodies or probes. The Trustees of Princeton University, Irving N Feit, Thomas C Gallagher, Laura S Weiss, December 1, 1998: US05843684 (6 worldwide citation)

The invention provides a method of diagnosing cancer by determining the expression level or gene amplification of p53 and dm2, whereby an elevated level of either p53 or dm2 or both p53 and dm2 indicates a cancer diagnosis. Furthermore, the invention provides a method of predicting the progress of c ...


5
Steven B Baim, Mark A Labow, Thomas E Shenk, Arnold J Levine: Eukaryotic cells comprising a DNA sequence encoding a bacterial-viral chimeric transactivator protein. The Trustees of Princeton University, Pennie & Edmonds, October 7, 1997: US05674730 (6 worldwide citation)

The present invention relates to novel chimeric transactivating proteins comprising a functional portion of a DNA binding protein and a functional portion of a transcriptional activator protein. The chimeric transactivating proteins of the invention offer a variety of advantages, including the speci ...


6
Gyan Vatsaraja Bhanot, Gabriele Alexe, Arnold J Levine, Babu Venkataraghavan: Method and system for robust classification strategy for cancer detection from mass spectrometry data. International Business Machines Corporation, McGinn IP Law Group PLLC, Vazken Alexanian, March 1, 2011: US07899625 (3 worldwide citation)

A robust classification method for cancer detection from mass spectrometry data includes inputting the mass spectrometry data, preprocessing the spectrometry data, conducting robust feature selection, generating predictions for the test data sets using multiple data classifiers, the multiple data cl ...


7
Arnold J Levine, Thomas E Shenk, Cathy A Finlay: Methods for detecting mutant p53. Trustees of Princeton University, Irving N Feit, Cheryl L Becker, Lawrence S Pope, April 15, 1997: US05620848 (3 worldwide citation)

A panel of probes detects and distinguishes between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells Each set of mutations gives rise to a phenotype that is different from that of wild-type p53 and of at least one other set of p53 m ...


8
Arnold J Levine, Diane Pennica: WISP polypeptides and nucleic acids encoding same. Genentech, Diane L Marschang, Ginger R Dreger, Heller Ehrman, September 5, 2006: US07101850 (1 worldwide citation)

Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides ...


9
Gyan Vatsaraja Bhanot, Gabriele Alexe, Arnold J Levine, Babu Venkataraghavan: Method and system for robust classification strategy for cancer detection from mass spectrometry data. International Business Machines Corporation, Vazken Alexanian, McGinn IP Law Group PLLC, May 20, 2014: US08731839 (1 worldwide citation)

A robust classification method for cancer detection from mass spectrometry data includes inputting the mass spectrometry data, preprocessing the spectrometry data, conducting robust feature selection, generating predictions for the test data sets using multiple data classifiers, the multiple data cl ...


10
Arnold J Levine, Uri Alon: Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays. Princeton University, Ritter Lang & Kaplan, December 3, 2002: US06489096

Systems and methods for enhanced quantitative analysis of hybridization intensity measurements obtained from oligonucleotide probes and other probes exposed to target samples are provided by virtue of the present invention. One embodiment ameliorates the effects of high frequency noise superimposed ...