1
Arnold I Caplan, Stephen E Haynesworth: Human mesenchymal stem cells. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, January 23, 1996: US05486359 (515 worldwide citation)

Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem cells" or "hMSCs"), and characterization of a ...


2
Arnold I Caplan, Stephen E Haynesworth: Method for treating connective tissue disorders. Fay Sharpe Beall Fagan Minnich & McKee, July 13, 1993: US05226914 (416 worldwide citation)

The present invention is directed to various processes and devices for utilizing isolated and culturally expanded marrow-derived mesenchymal cells (i.e. mesenchymal stem cells) for treating skeletal and other connective tissue disorders.


3
Arnold I Caplan, Stephen E Haynesworth: Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells. Fay Sharpe Beall Fagan Minnich & McKee, March 30, 1993: US05197985 (343 worldwide citation)

The present invention is directed to a method and device for enhancing the implantation and differentiation of marrow-derived mesenchymal cells (i.e. mesenchymal stem cells). The method and device of the invention are an effective means for treating skeletal and other connective tissue disorders.


4
Arnold I Caplan, Stephen E Haynesworth: Connective tissue regeneration using human mesenchymal stem cell preparations. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, September 22, 1998: US05811094 (264 worldwide citation)

Isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therap ...


5
Victor M Goldberg, Arnold I Caplan, Francis P Barry, David J Fink, Daniel R Marshak, James S Burns: Osteoarthritis cartilage regeneration. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, December 28, 2004: US06835377 (194 worldwide citation)

For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) ...


6
Arnold I Caplan, David J Fink, Randell G Young: Biomatrix for soft tissue regeneration. Case Western Reserve University, January 5, 1999: US05855619 (193 worldwide citation)

An implant for repair of a tissue defect which implant comprises a physiologically compatible load-bearing member having an element for securing under tension tissue adjacent to the defect to be repaired, an element for supporting a tissue reparative cell mass in the defect and a tissue reparative c ...


7
Stanton L Gerson, Arnold I Caplan, Stephen E Haynesworth: Transduced mesenchymal stem cells. Case Western Reserve University, Charles J Herron, Elliot M Olstein, January 7, 1997: US05591625 (174 worldwide citation)

Genetically engineered human stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins or for use in gene therapy. In addition to correction of genetic disorders, is the ability to introduce, in a targeted manner, addi ...


8
Scott P Bruder, Arnold I Caplan, Stephen E Haynesworth: Lineage-directed induction of human mesenchymal stem cell differentiation. Case Western Reserve University, Charles J Herron, Elliot M Olstein, April 7, 1998: US05736396 (165 worldwide citation)

Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including i ...


9
Scott P Bruder, Arnold I Caplan, Stephen E Haynesworth: Lineage-directed induction of human mesenchymal stem cell differentiation. Case Western Reserve University, Osiris Therapeutics, Elliot M Olstein, Raina Semionow, August 24, 1999: US05942225 (153 worldwide citation)

Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including i ...


10
Sudhakar Kadiyala, Arnold I Caplan, David J Fink, Randall G Young: Biomatrix for soft tissue regeneration using mesenchymal stem cells. Osiris Therapeutics, Case Western Reserve University, Elliot M Olstein, William Squire, Carella Byrne et al, January 16, 2001: US06174333 (108 worldwide citation)

An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supporte ...