1
Bartholomaeus Johannes Dr, Kugelmann Heinrich, Arkenau Maric Elisabeth Dr: Dosage form that is secured against misuse. Gruenenthal, November 28, 2007: EP1859789-A1 (48 worldwide citation)

Abuse-proofed, thermoformed dosage form (C1) comprises an active ingredient with abuse potential (A) optionally together with physiologically acceptable auxiliary substances (B), synthetic or natural polymer (P1) and optionally at least one wax (D). (P1) Exhibits a breaking strength of at least 500 ...


2
Bartholomäus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth: (De) Gegen missbrauch gesicherte, orale darreichtungsform, (En) Oral dosage form safeguarded against abuse. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth, KUTZENBERGER Helga, January 12, 2006: WO/2006/002884 (40 worldwide citation)

(EN) The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled opioid release for a once daily administering. The invention is characterized in that the oral dosage form comprises at least one opioid with an abuse potential (A), at least one syntheti ...


3
Bartholomaeus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth Dr: Form of administration secured against misuse. Gruenenthal, May 24, 2006: EP1658055-A1 (33 worldwide citation)

The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of a ...


4
Bartholomäus Johannes, Arkenau Maric Elisabeth: (De) Verfahren zur herstellung einer gegen missbrauch gesicherten darreichungsform, (En) Method for the production of an administration form which is secured against misuse. Grünenthal, Bartholomäus Johannes, Arkenau Maric Elisabeth, KUTZENBERGER Helga, July 14, 2005: WO/2005/063214 (33 worldwide citation)

(EN) The invention relates to a method for the production of thermoformed administration forms, which are secured against misuse, containing at least one synthetic or natural polymer with a breaking resistance of at least 500 N, in addition to one or several active substances having a misuse potenti ...


5
Ashworth Judy, Arkenau Maric Elisabeth, Bartholomäus Johannes: (De) Bruchfeste darreichungsformen mit retardierter freisetzung, (En) Break-resistant delayed-release forms of administration. Grünenthal, Ashworth Judy, Arkenau Maric Elisabeth, Bartholomäus Johannes, KUTZENBERGER Helga, August 10, 2006: WO/2006/082099 (28 worldwide citation)

(EN) The invention relates to a form of administration comprising a physiologically effective substance (A); one or several optional physiologically acceptable adjuvants (B); a synthetic or natural polymer (C); and an optional natural, semisynthetic, or synthetic wax (D). Said form of administration ...


6
Jans Eugeen Marie Jozef, Kiekens Filip René Irena, Voorspoels Jody Firmin Marceline, Faure Anne, Arkenau Maric Elisabeth, Barnscheid Lutz, Bartholomäus Johannes, Frevel Marc, Galia Eric, Ziegler Iris: Pharmaceutical dosage form. Grünenthal, Jans Eugeen Marie Jozef, Kiekens Filip René Irena, Voorspoels Jody Firmin Marceline, Faure Anne, Arkenau Maric Elisabeth, Barnscheid Lutz, Bartholomäus Johannes, Frevel Marc, Galia Eric, Ziegler Iris, BÜLLE Jan, July 30, 2009: WO/2009/092601 (28 worldwide citation)

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacoiogicaiiy active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in directi ...


7
Arkenau Maric Elisabeth, Bartholomäus Johannes: (De) Verfahren zur herstellung einer gegen missbrauch gesicherten darreichungsform, (En) Method for the production of a tamper-proof form of administration. Grünenthal, Arkenau Maric Elisabeth, Bartholomäus Johannes, KUTZENBERGER Helga, August 10, 2006: WO/2006/082097 (27 worldwide citation)

(EN) The invention relates to a method for producing a tamper-proof form of administration containing at least one synthetic or natural polymer (C) having a minimum breaking strength of 500 N in addition to one or several tamper-prone agents and optional physiologically acceptable adjuvants. A solve ...


8
Arkenau Maric Elisabeth, Bartholomäus Johannes, Ziegler Iris, Haupts Marcel: (De) Darreichungsform mit erschwertem missbrauch, (En) Pharmaceutical form with impeded abuse. Grünenthal, Arkenau Maric Elisabeth, Bartholomäus Johannes, Ziegler Iris, Haupts Marcel, KUTZENBERGER Helga, September 12, 2008: WO/2008/107149 (26 worldwide citation)

(EN) The present invention relates to a multiparticulate pharmaceutical form with impeded abuse including at least one active ingredient with the potential for abuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic, or synthetic wax (D), at least on ...


9
Ashworth Judy, Arkenau Maric Elisabeth, Bartholomaeus Johannes, Kugelmann Heinrich: Formes galeniques resistantes a la rupture a liberation retardee, Break-resistant delayed release forms of administration. Gruenenthal, Gruenenthal, Fetherstonhaugh & Co, January 18, 2011: CA2595954 (17 worldwide citation)

The invention relates to a form of administration comprising a physiologically effective substance (A); one or several optional physiologically acceptable adjuvants (B); a synthetic or natural polymer (C); and an optional natural, semisynthetic, or synthetic wax (D). Said form of administration is p ...


10
Bartholomaeus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth: Oral dosage form safeguarded against abuse. Gruenenthal, March 28, 2007: EP1765303-A1 (16 worldwide citation)

The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled opioid release for a once daily administering. The invention is characterized in that the oral dosage form comprises at least one opioid with an abuse potential (A), at least one synthetic and ...