Antonin Holy, Erik Desire Alice De Clercq: N.sup.6 - substituted nucleotide analagues and their use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, November 2, 1999: US05977061 (104 worldwide citation)

Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivira ...

Antonin Holy, Hana Dvorakova, Erik Desire Alice DeClercq, Jan Marie Rene Balzarini: Antiretroviral enantiomeric nucleotide analogs. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, May 2, 2000: US06057305 (71 worldwide citation)

Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.

Antonin Holy, Ivan Rosenberg: 9-(phosponylmethoxyalkyl) adenines, the method of preparation and utilization thereof. Ceskoslovenska akademic ved, Leydig Voit Mayer, February 28, 1989: US04808716 (71 worldwide citation)

The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R.sup.2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylen ...

Antonin Holy, Ivan Rosenberg, Erik D A De Clercq: N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity. Ceskoslovenska Akademie Ved, Rega Institut, Leydig Voit & Mayer, August 25, 1992: US05142051 (68 worldwide citation)

This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible ...


Erik De Clercq, Antonin Holy, Ivan Rosenberg: Therapeutical application of phosphonylmethoxyalkyl adenines. Stichting Rega VZW, Ceskoslovenska Akademie VED, Birch Stewart Kolasch & Birch, February 9, 1988: US04724233 (53 worldwide citation)

The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.

Antonin Holy, Ivan Rosenberg, Karel Slama: Isomeric O-phosphonylmethyl derivatives of enantiomeric and racemic 9-(2,3-dihydroxypropyl)adenine. Ceskoslovenska akademie, Leydig Voit & Mayer, April 21, 1987: US04659825 (29 worldwide citation)

This invention relates to isomeric O-phosphonylmethyl derivatives of the formula I ##STR1## wherein R.sup.5 designates an adenin-9-yl moiety, R.sup.4 are alternately a hydrogen atom and a --CH.sub.2 P(O)(OH).sub.2 group, and the configuration at the carbon atom in the position 2 is S, R or RS.

Petr Alexander, Antonin Holy, Hana Dvorakova: (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-to luenesulfonyloxy-1-trimethylacetoxypropane, its preparation and use. Ceskoslovenska akademie ved, Notaro & Michalos, July 14, 1992: US05130427 (12 worldwide citation)

The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine ...

Antonin Holy, Erik de Clercq: Antivirally active adenine derivatives. Ceskoslovenska Akademie Ved, Stichting Rega VZW, Birch Stewart Kolasch & Birch, August 12, 1986: US04605658 (11 worldwide citation)

Certain esters of 3-(adenin-9-yl)-2-hydroxypropanoic acid are disclosed which exhibit an improved broad spectrum antiviral activity while having a low toxicity for living cells. They can be used for treatment of virus diseases in human and veterinary practice.

Erik De Clercq, Antonin Holy: Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents. Stichting Rega V Z W, Ceskoslovenska Akademie Ved, Brumbaugh Graves Donohue & Raymond, October 28, 1980: US04230708 (11 worldwide citation)

The specification describes the use of S or RS 9-(2, 3-dihydroxypropyl) adenine either alone or in combination with ara-A for the treatment of virus diseases.