1
Akin Akinc, Antonin De Fougerolles, Hans Peter Vornlocher, Philipp Hadwiger, Birgit Bramlage: RNAi modulation of HIF-1 and therapeutic uses thereof. Alnylam Pharmaceuticals, Fenwick & West, June 15, 2010: US07737265 (71 worldwide citation)

The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of HIF-1α, such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.


2
Jason P Schrum, Noubar B Afeyan, Gregory J Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M Elbashir: Engineered nucleic acids encoding a modified erythropoietin and their expression. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, April 29, 2014: US08710200 (40 worldwide citation)

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.


3
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Modified polynucleotides for the production of G-CSF. Moderna Therapeutics, DT Ward P C, Donna T Ward, Jennifer F Bryan, March 25, 2014: US08680069 (38 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


4
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: Method for producing a protein of interest in a primate. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, March 4, 2014: US08664194 (26 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


5
Antonin de Fougerolles, Kristy M Wood, Sayda M Elbashir, Jason P Schrum: DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides. Moderna Therapeutics, DT Ward P C, Jennifer F Bryan, June 17, 2014: US08754062 (24 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


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7
Cynthia Green, Victor Kotelianski, Antonin de Fougerolles, John Carulli, Catherine Hession: Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same. CuraGen Corporation, Biogen, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, August 6, 2002: US06429303 (18 worldwide citation)

An isolated BLAA polynucleotide and the membrane-associated or secreted polypeptide encoded by the BLAA polynucleotide are disclosed. Also disclosed are the antibodies that immunospecifically bind to a BLAA polypeptide or any derivative, variant, mutant or fragment of the BLAA polypeptide, polynucle ...


8
Stephen G Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth: Compositions and methods of altering cholesterol levels. Moderna Therapeutics, DT Ward PC, Donna T Ward, Jennifer F Bryan, March 17, 2015: US08980864 (9 worldwide citation)

The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.


9
Antonin de Fougerolles, Sayda M Elbashir: Split dose administration. MODERNA THERAPEUTICS, DT WARD PC, Donna T Ward, Jennifer F Bryan, November 17, 2015: US09186372 (8 worldwide citation)

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified n ...


10
Tirtha Chakraborty, Antonin de Fougerolles: Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1. Moderna Therapeutics, DT WARD PC, Donna T Ward, Jennifer F Bryan, August 4, 2015: US09095552 (8 worldwide citation)

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.