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Anton F J Fliri, Brian T O Neill, William S Faraci, Mark A Sanner, Stevin H Zorn: Benzimidazolone derivatives with central dopaminergic activity. Pfizer, Peter C Richardson, Paul H Ginsburg, Karen Debenedictis, March 16, 1999: US05883094 (17 worldwide citation)

This invention relates to novel, pharmaceutically active benzimidazolone derivatives of the formula ##STR1## wherein the dashed line, R.sup.0 through R.sup.6 and X.sup.1 through X.sup.3 are defined as in the specification. These compounds exhibit central dopaminergic activity and are u in the treatm ...


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Rodney C Schnur, Anton F J Fliri: Benzamide protease inhibitors. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, October 17, 1989: US04874864 (15 worldwide citation)

Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors use as anti-plasmin and anti-thrombin agents.


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Rodney C Schnur, Anton F J Fliri: Benzamide protease inhibitors. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, August 14, 1990: US04948891 (13 worldwide citation)

Compounds of the formula ##STR1## where Het is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and anti-thrombin agents.


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Rodney C Schnur, Anton F J Fliri: Benzamide protease inhibitors. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, August 14, 1990: US04948901 (9 worldwide citation)

Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and antithrombin agents.


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Kishor A Desai, Anton F J Fliri, Mark A Sanner: 2,7-substituted octahydro-1H-pyrido�1,2-a!pyrazine derivatives. Pfizer, Peter C Richardson, Gregg C Benson, Mervin E Brokke, December 22, 1998: US05852031 (5 worldwide citation)

Substituted pydrido�1,2-a!pyrazines of general formula I wherein Ar and Ar.sup.1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO.sub.2, C.dbd.O, CHOH, or --(CR.sup.3 R.sup.4) and n is 0-2 as well as precursors thereto are ligands for dopamine receptor subtype ...


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William S Faraci, Anton F J Fliri, Brian T O Neill, Mark A Sanner, Stevin H Zorn: Benzimidazole derivatives having dopaminergic activity. Pfizer, Peter C Richardson, Paul H Ginsburg, Raymond M Speer, March 30, 1999: US05889010 (4 worldwide citation)

Pharmaceutically active benzimidazole derivatives are disclosed comprising compounds of the formula: ##STR1## particularly wherein X is nitrogen, R.sup.1 is phenyl or heteroaryl, and one of R.sup.2 or R.sup.3 is hydroxy. Said compounds have D4 dopaminergic receptor binding activity and consequently ...


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